2. Autophagy Apoptosis
  3. Autophagy Mitophagy Ferroptosis
  4. Hemin

Hemin  (Synonyms: 氯化血红素; Hemin chloride)

目录号: HY-19424 纯度: 99.16%
COA 产品使用指南

摩尔计算器

Hemin 是含铁的卟啉化合物。Hemin 是血红素加氧酶 (HO)-1 诱导剂。

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Hemin Chemical Structure

Hemin Chemical Structure

CAS No. : 16009-13-5

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规格 价格 是否有货 数量
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g ￥1800
In-stock
10 g   询价  
50 g   询价  

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Customer Review

Hemin 相关抗体

Top Publications Citing Use of Products

    Hemin purchased from MCE. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259.  [Abstract]

    Hemin (0, 20, 40, 80 µM; 2 h) increases G4 levels in a dose-dependent manner in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.

    IC50 & Target

    Heme oxygenase[1]
    体外研究
    (In Vitro)

    Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Hemin 相关抗体:
    体内研究
    (In Vivo)

    Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    651.94

    Formula

    C34H32ClFeN4O4
    CAS 号
    性状

    固体

    颜色

    Dark purple to black

    中文名称

    氯化血红素；血晶素；氯化高铁血红素
    结构分类
    初始来源

    Red blood cells
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)

    溶解性数据
    In Vitro: 

    1M NaOH 中的溶解度 : 6.67 mg/mL (10.23 mM; 超声助溶; 碱性条件溶解 (NaOH 调节，pH≈11))

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.5339 mL 7.6694 mL 15.3388 mL
    5 mM 0.3068 mL 1.5339 mL 3.0678 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.16%

    COA (202 KB) LCMS (94 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    For the cell proliferation assay, cells are seeded into 96 well (5-12.5×104 cells per mL according to the cell line) and kept at 37°C and 5 % CO2. After 24 h, cells are treated with statins or/and Hemin, followed by the MTT test as a general cell proliferation assay[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Mice[2]
    Eight- to ten-week-old male BABL/c mice are used for the ischemia-reperfusion (I/R) experiments. The animals are divided into five groups as follows: (1) the sham group undergo isolation of the bilateral renal arteries without clamping; (2) the vehicle group receive an intraperitoneal (i.p.) injection of 4 mL/kg PBS as a vehicle control (with IRI); (3) the Hemin-preconditioned group receive Hemin, a potent inducer of HO-1, at 100 μmol/kg i.p.; (4) the Hemin plus ZnPP group receive zinc protoporphyrin IX, an inhibitor of HO-1 activity, at 5 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p.; and (5) the Hemin plus PD98059 group receive PD98059, an inhibitor of ERK1/2 activity, at 10 mg/kg i.p. 6 h after receiving 100 μmol/kg Hemin i.p. Both inhibitors are administered i.p. 2 h before I/R, whereas Hemin was administered 8 h before I/R.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Hemin 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    1M NaOH 1 mM 1.5339 mL 7.6694 mL 15.3388 mL 38.3471 mL
    5 mM 0.3068 mL 1.5339 mL 3.0678 mL 7.6694 mL
    10 mM 0.1534 mL 0.7669 mL 1.5339 mL 3.8347 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Hemin16009-13-5氯化血红素血晶素氯化高铁血红素AutophagyMitophagyFerroptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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