1. PROTAC
  2. Ligand for E3 Ligase
    PROTAC
  3. Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1 

目录号: HY-111593
产品使用指南

Homo-PROTAC pVHL30 degrader 1 是基于 PROTAC 的有效 pVHL30 降解剂。

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Homo-PROTAC pVHL30 degrader 1 Chemical Structure

Homo-PROTAC pVHL30 degrader 1 Chemical Structure

CAS No. : 2244684-49-7

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Description

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].

IC50 & Target

pVHL30[1]
PROTAC[1]

In Vitro

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1179.45

Formula

C₅₈H₈₂N₈O₁₄S₂

CAS No.

2244684-49-7

SMILES

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@]([H])(O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Homo-PROTAC pVHL30 degrader 1
目录号:
HY-111593
需求量:

Homo-PROTAC pVHL30 degrader 1

Cat. No.: HY-111593