1. NF-κB
  2. IKK

INH14 

目录号: HY-114454 纯度: >98.0%
产品使用指南

INH14 是 IKKα/IKKβ 的抑制剂,IC50 值分别为 8.97 和 3.59 μM。INH14 抑制 TAK1/TAB1 的下游和 NF-kB 信号通路。具有抗炎和抗癌作用。

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INH14 Chemical Structure

INH14 Chemical Structure

CAS No. : 200134-22-1

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Description

INH14 is an inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].

IC50 & Target[1]

IKKβ

3.59 μM (IC50)

IKKα

8.97 μM (IC50)

In Vivo

INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1].

Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1]
Dosage: 5 µg/g, one hour before Pam2CSK4 injection
Administration: I.P. for 2 hours
Result: Decreased TNFα production in mice.
References
Molecular Weight

240.30

Formula

C₁₅H₁₆N₂O

CAS No.

200134-22-1

SMILES

O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
INH14
目录号:
HY-114454
需求量:

INH14

Cat. No.: HY-114454