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JI051 

目录号: HY-117113
产品使用指南

JI051 是一种 Hes1-PHB2 相互作用稳定剂,能够与癌症相关蛋白伴侣 prohibitin 2 (PHB2) 相互作用,通过抑制 Notch 下游效应基因 Hes1 来诱导细胞周期停滞。具有抗肿瘤作用。

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JI051 Chemical Structure

JI051 Chemical Structure

CAS No. : 2234281-75-3

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5 mg ¥4500 Get quote
10 mg ¥7500 Get quote
50 mg ¥22500 Get quote
100 mg ¥35000 Get quote

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Description

JI051 is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].

In Vitro

JI051 causes G2/M cell-cycle arrest, inhibits cell proliferation of HEK293 cells, with an EC550 of 0.3 μM[1].

References
Molecular Weight

364.44

Formula

C₂₂H₂₄N₂O₃

CAS No.

2234281-75-3

SMILES

O=C(NCCC1=CC=CC=C1OCC)/C=C/C2=CNC3=C2C=CC=C3OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
JI051
目录号:
HY-117113
需求量:

JI051

Cat. No.: HY-117113