1. Epigenetics
  2. Histone Methyltransferase
  3. JNJ-64619178

JNJ-64619178 

目录号: HY-101564 纯度: 98.56%
产品使用指南

JNJ-64619178 是一种伪不可逆的,选择性 PRMT5 抑制剂,IC50 为 0.14 nM。

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JNJ-64619178 Chemical Structure

JNJ-64619178 Chemical Structure

CAS No. : 2086772-26-9

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3084 In-stock
1 mg ¥1000 In-stock
5 mg ¥2900 In-stock
10 mg ¥4900 In-stock
50 mg ¥19000 In-stock
100 mg ¥29000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

JNJ-64619178 is a selective and pseudo-irreversible PRMT5 inhibitor with an IC50 of 0.14 nM[1][2].

IC50 & Target

IC50: 0.14 nM (PRMT5)[2]

In Vitro

JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. JNJ-64619178 shows potent and broad inhibition of cellular growth[1].

In Vivo

Oral administration of JNJ-64619178 results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer cancer mouse xenograft models[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (258.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0689 mL 10.3443 mL 20.6885 mL
5 mM 0.4138 mL 2.0689 mL 4.1377 mL
10 mM 0.2069 mL 1.0344 mL 2.0689 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.30 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.30 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.30 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

483.36

Formula

C₂₂H₂₃BrN₆O₂

CAS No.

2086772-26-9

SMILES

BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
JNJ-64619178
目录号:
HY-101564
需求量:

JNJ-64619178

Cat. No.: HY-101564