1. Protein Tyrosine Kinase/RTK
  2. c-Fms

JTE-952 

目录号: HY-122906
产品使用指南

JTE-952 是 集落刺激因子-1 受体 (CSF-1R/cFMS) 有效的、具有口服活性的、 II 型 选择性抑制剂,其对 CSF1R 和 TrkA 的IC50 值分别为 13 nM 和 261 nM。可用于治疗关节炎。

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JTE-952 Chemical Structure

JTE-952 Chemical Structure

CAS No. : 1255303-54-8

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Description

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

IC50 & Target

IC50: 13 nM (CSF1R), 261 nM (TrkA)[1].

In Vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].

Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1].
Dosage: 3 mg/kg.
Administration: Oral once-daily.
Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion.
References
Molecular Weight

518.60

Formula

C₃₀H₃₄N₂O₆

CAS No.

1255303-54-8

SMILES

O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
JTE-952
目录号:
HY-122906
需求量:

JTE-952

Cat. No.: HY-122906