1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. JTE-952

JTE-952 

目录号: HY-122906
产品使用指南

JTE-952 是 集落刺激因子-1 受体 (CSF-1R/cFMS) 有效的、具有口服活性的、 II 型 选择性抑制剂,其对 CSF1R 和 TrkA 的IC50 值分别为 13 nM 和 261 nM。可用于治疗关节炎。

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JTE-952 Chemical Structure

JTE-952 Chemical Structure

CAS No. : 1255303-54-8

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Description

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

IC50 & Target

IC50: 13 nM (CSF1R), 261 nM (TrkA)[1].

In Vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].

Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1].
Dosage: 3 mg/kg.
Administration: Oral once-daily.
Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

518.60

Formula

C₃₀H₃₄N₂O₆

CAS No.

1255303-54-8

SMILES

O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
JTE-952
目录号:
HY-122906
需求量:

JTE-952

Cat. No.: HY-122906