2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. KU-32

KU-32是一种新型的，基于新生霉素的 Hsp90 抑制剂，可以预防神经细胞死亡。

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KU-32 Chemical Structure

KU-32 Chemical Structure

CAS No. : 956498-70-7

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KU-32 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.

IC50 & Target

Hsp90[1]
体外研究
(In Vitro)

Treating human islets with KU-32 for 24 hours shows no toxicity. With a minimum of 2-day exposure, KU-32 improves cellular viability by blocking apoptosis. Functionally, isolated human islets release more glucose-stimulated insulin when preincubate in KU-32[1]. KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KU-32 相关抗体:
体内研究
(In Vivo)

Diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks do not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

407.41

Formula

C20H25NO8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay
[1]

Islets are placed into 96-well plates and subjected to a 8-point dose of KU-32 in either low (5 mM) or high (17.5 mM) glucose in DMEM : F12 media and incubated overnight at 37°C and 5% CO2. Twenty-four hours later, alamarBlue is added directly to each well to achieve a final concentration of 10% alamarBlue. Readings on a microplate reader are collected 4, 24, and 48 hours later[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration

Male and female lepr mice are used. At 10 weeks of age, animals are given once per week intraperitoneal injection of 5% Captisol or 20 mg/kg KU-32 in 5% Captisol. At termination of the study, blood from each animal is collected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

KU-32 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KU-32956498-70-7KU32KU 32HSPHeat shock proteinsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-108248
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