2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
  4. L-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid  (Synonyms: (S)-2-Hydroxyglutaric acid)

目录号: HY-113039
COA 产品使用指南

摩尔计算器

L-2-Hydroxyglutaric acid ((S)-2-Hydroxyglutaric acid) 是一种表观遗传修饰因子，可用于肾癌研究。L-2-Hydroxyglutaric acid 可抑制组蛋白去甲基化酶 (histone demethylases)，从而促进组蛋白甲基化。

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L-2-Hydroxyglutaric acid Chemical Structure

L-2-Hydroxyglutaric acid Chemical Structure

CAS No. : 13095-48-2

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规格 价格 是否有货 数量
5mg （67.52 mM * 0.5 mL in Ethanol） ￥2400
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25 mg
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Other Forms of L-2-Hydroxyglutaric acid:

L-2-Hydroxyglutaric acid 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-2-Hydroxyglutaric acid 相关抗体:
分子量

148.11

Formula

C5H8O5
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

L-2-羟基戊二酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥95.0%

COA (260 KB)

产品使用指南 (1538 KB)
参考文献

L-2-Hydroxyglutaric acid 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-2-Hydroxyglutaric acid13095-48-2(S)-2-Hydroxyglutaric acidL-2-羟基戊二酸Histone DemethylaseMitochondrial MetabolismEndogenous MetaboliteepigeneticmodifierrenalcancerhistonedemethylasesmethylationInhibitorinhibitorinhibit

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