1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

Lavendustin A (Synonyms: RG-14355)

目录号: HY-18963
产品使用指南

Lavendustin A (RG-14355), 可从Streptomyces Griseolavendus 中分离得到,是一种有效的、特异性的、ATP竞争性的酪氨酸激酶抑制剂,对表皮生长因子受体 (EGFR) 相关酪氨酸激酶的 IC50 值为 11 ng/mL。 能抑制血管内皮生长因子诱导的血管生成,阻断LTPGABA-A的诱导。

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Lavendustin A Chemical Structure

Lavendustin A Chemical Structure

CAS No. : 125697-92-9

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Description

Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3].

IC50 & Target

IC50: 11 ng/mL (EGFR-associated tyrosine kinase)[1].

References
Molecular Weight

381.38

Formula

C₂₁H₁₉NO₆

CAS No.

125697-92-9

SMILES

O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Lavendustin A
目录号:
HY-18963
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Lavendustin A

Cat. No.: HY-18963