1. Metabolic Enzyme/Protease
  2. Cathepsin

MK-0674 

目录号: HY-10290
产品使用指南

MK-0674 是一种有效、可口服、选择性的 cathepsin K 抑制剂,IC50 值为 0.4 nM,对其选择性分别是 Cat B,Cat F,Cat L 和 Cat S 的 1156,1465,11857 和 243 倍。

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MK-0674 Chemical Structure

MK-0674 Chemical Structure

CAS No. : 887781-62-6

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Description

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].

IC50 & Target

IC50: 0.4 nM (Cathepsin K)[1]

In Vitro

MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].

References
Molecular Weight

527.50

Formula

C₂₆H₂₇F₆N₃O₂

CAS No.

887781-62-6

SMILES

N#CC1(CC1)NC([C@H](CC(C)(C)F)N[C@@H](C2=CC=C(C3=CC=C(C=C3)[C@@H](O)C(F)F)C=C2)C(F)(F)F)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
MK-0674
目录号:
HY-10290
需求量:

MK-0674

Cat. No.: HY-10290