1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mebeverine hydrochloride

Mebeverine hydrochloride  (Synonyms: 美贝维林盐酸盐;盐酸麦皮凡林;甲苯凡林盐酸盐)

目录号: HY-A0078 纯度: 99.71%
COA 产品使用指南

Mebeverine hydrochloride 是 β-苯乙胺的衍生物,一种增肌剂,可有效阻止肠道蠕动。Mebeverine hydrochloride直接阻断电压控制的钠通道 (voltage-operated sodium channels),抑制细胞内钙的积累。

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Mebeverine hydrochloride Chemical Structure

Mebeverine hydrochloride Chemical Structure

CAS No. : 2753-45-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥718
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5 mg ¥700
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10 mg ¥1050
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25 mg ¥2100
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50 mg ¥3400
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100 mg ¥5500
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500 mg   询价  

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Other Forms of Mebeverine hydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation[1][2].

体外研究
(In Vitro)

Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

466.01

Formula

C25H36ClNO5

CAS 号
性状

固体

颜色

White to off-white

中文名称

美贝维林盐酸盐;盐酸麦皮凡林;甲苯凡林盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 155 mg/mL (332.61 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1459 mL 10.7294 mL 21.4588 mL
5 mM 0.4292 mL 2.1459 mL 4.2918 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.71%

参考文献

Mebeverine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1459 mL 10.7294 mL 21.4588 mL 53.6469 mL
5 mM 0.4292 mL 2.1459 mL 4.2918 mL 10.7294 mL
10 mM 0.2146 mL 1.0729 mL 2.1459 mL 5.3647 mL
15 mM 0.1431 mL 0.7153 mL 1.4306 mL 3.5765 mL
20 mM 0.1073 mL 0.5365 mL 1.0729 mL 2.6823 mL
25 mM 0.0858 mL 0.4292 mL 0.8584 mL 2.1459 mL
30 mM 0.0715 mL 0.3576 mL 0.7153 mL 1.7882 mL
40 mM 0.0536 mL 0.2682 mL 0.5365 mL 1.3412 mL
50 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0729 mL
60 mM 0.0358 mL 0.1788 mL 0.3576 mL 0.8941 mL
80 mM 0.0268 mL 0.1341 mL 0.2682 mL 0.6706 mL
100 mM 0.0215 mL 0.1073 mL 0.2146 mL 0.5365 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Mebeverine hydrochloride
目录号:
HY-A0078
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