2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. Melanin Concentrating Hormone, salmon

Melanin Concentrating Hormone, salmon  (Synonyms: MCH (salmon))

目录号: HY-P1525 纯度: 98.40%
COA 产品使用指南

摩尔计算器

Melanin Concentrating Hormone, salmon是最初在硬骨鱼的垂体中发现的19个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。 Melanin-concentrating hormone是 SLC-1/GPR24 和 MCHR2 的配体。

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Custom Peptide Synthesis

Melanin Concentrating Hormone, salmon Chemical Structure

Melanin Concentrating Hormone, salmon Chemical Structure

CAS No. : 87218-84-6

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规格 价格 是否有货 数量
500 μg ￥1400
In-stock
1 mg ￥2200
In-stock
5 mg ￥8800
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Melanin Concentrating Hormone, salmon:

Melanin Concentrating Hormone, salmon 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

IC50 & Target

SLC-1/GPR24, MCHR2[1]
体外研究
(In Vitro)

An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Melanin Concentrating Hormone, salmon 相关抗体:
体内研究
(In Vivo)

Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days[2]. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2099.48

Formula

C89H139N27O24S4
CAS 号
性状

固体

颜色

White to off-white

Sequence

Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val (Disulfide bridge: Cys5-Cys14)
Sequence Shortening

DTMRCMVGRVYRPCWEV (Disulfide bridge: Cys5-Cys14)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (47.63 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4763 mL 2.3815 mL 4.7631 mL
5 mM 0.0953 mL 0.4763 mL 0.9526 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Kinase Assay
[1]

Binding of 125I-labeled Melanin Concentrating Hormone (MCH) to MCHR1 and MCHR2 is measured by filtration binding assay. Membranes (10 μg protein) from transiently transfected HEK293-MCHR1 and HEK293-MCHR2 cells are mixed with 0-9.8 nM 125I-labeled MCH in the binding buffer (50 mM Hepes/10 mM MgCl内容2/2 mM EGTA; protease inhibitors, 0.1% BSA, pH 7.6). After incubation for 1 h at room temperature, membrane-bound 125I-labeled MCH is separated from the free 125I-labeled MCH by filtration through a 96-well GF/B plate on a Packard Filtermate Cell Harvester and ished with ice-cold binding buffer supplemented with 80 mM NaCl. Eighty microliters of scintillation liquid is added, and the radioactivity is counted on a Packard Microplate Topcount[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2][3]

Rats[2]

Both male Wistar and male Sprague-Dawley rats weighing between 310 and 370 g (age 8-11 weeks) are used in the study. All animals receive food which had the following dry weight composition: 64% carbohydrate, 22% protein, 4.3% fat, 4% cellulose and 5.5% ash. For chronic experiments, the rats are infused either with artificial CSF (0.5 μL/h) or MCH (8 μg/rat/day).Body weight and food intake are then recorded daily for 12 days[2].

Mice[3]

Male C57BL/6J mice is prepared for measurement of spontaneous motor activity. Melanin Concentrating Hormone (10 μg/day) or the vehicle is infused for 14 days under the regular diet-fed condition. Motor activity is measured during the last 3 days of the 14-day infusion by an activity monitoring system in home cages[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Melanin Concentrating Hormone, salmon 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4763 mL 2.3815 mL 4.7631 mL 11.9077 mL
5 mM 0.0953 mL 0.4763 mL 0.9526 mL 2.3815 mL
10 mM 0.0476 mL 0.2382 mL 0.4763 mL 1.1908 mL
15 mM 0.0318 mL 0.1588 mL 0.3175 mL 0.7938 mL
20 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5954 mL
25 mM 0.0191 mL 0.0953 mL 0.1905 mL 0.4763 mL
30 mM 0.0159 mL 0.0794 mL 0.1588 mL 0.3969 mL
40 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2977 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melanin Concentrating Hormone, salmon87218-84-6MCH (salmon)MCHR1 (GPR24)Melanin concentrating hormone receptor 1Inhibitorinhibitorinhibit

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