1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Microcystin-LR

Microcystin-LR  (Synonyms: Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))

目录号: HY-P0072
COA 产品使用指南

Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制剂,其 IC50 值分别为 1.7 nM,0.04 nM。

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Microcystin-LR Chemical Structure

Microcystin-LR Chemical Structure

CAS No. : 101043-37-2

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
50 μg (0.5 mM * 100 μL in Ethanol) ¥2150
In-stock
100 μg (0.5 mM * 200 μL in Ethanol) ¥3650
In-stock

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.

IC50 & Target

IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1].

体外研究
(In Vitro)

Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

995.17

Formula

C49H74N10O12

CAS 号
性状

液体

颜色

Colorless to light yellow

Sequence Shortening

ADALD-{Bas}-R-{Oaa}-D-{Ggu}

中文名称

微囊藻毒素-LR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 0.5 mg/mL (0.50 mM; 超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.0%

参考文献

Microcystin-LR 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Microcystin-LR
目录号:
HY-P0072
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