2. Anti-infection
  3. Fungal Antibiotic
  4. Moniliformin sodium salt

Moniliformin sodium salt  (Synonyms: 串珠镰刀菌素钠盐)

目录号: HY-101905 纯度: 99.50%
COA 产品使用指南

摩尔计算器

Moniliformin sodium salt是提取自镰孢镰刀菌中的有效的霉菌毒素。

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Moniliformin sodium salt Chemical Structure

Moniliformin sodium salt Chemical Structure

CAS No. : 71376-34-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2245
In-stock
1 mg ￥1700
In-stock
5 mg ￥3600
In-stock
10 mg ￥5700
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Moniliformin sodium salt 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Moniliformin sodium salt is a potent mycotoxin isolate from Fusarium moniliforme.

体外研究
(In Vitro)

Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate[1]. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Moniliformin sodium salt 相关抗体:
体内研究
(In Vivo)

Moniliformin is less toxic to mice, with an LD50 of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD50 of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors[1]. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

120.04

Formula

C4HNaO3
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

串珠镰刀菌素钠盐
结构分类
初始来源

Fusarium moniliforme
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (833.06 mM; 超声助溶)

DMSO 中的溶解度 : ≥ 45 mg/mL (374.88 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 8.3306 mL 41.6528 mL 83.3056 mL
5 mM 1.6661 mL 8.3306 mL 16.6611 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 33.33 mg/mL (277.66 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Animal Administration
[1][3]

Rats: Moniliformin is prepared in water. In this experiment, 5 dose groups (3, 6, 9, 12 and 15 mg/kg moniliformin b.w.) of test animals are exposed to moniliformin for 28 days. Each group consists of 5 male Sprague-Dawley rats. The dose groups are determined based on our acute toxicity study of MON in rats. In addition, a control group administered with filtered tap water and two satellite groups (dosed 12 and 15 mg/kg b.w. moniliformin) are used. The two satellite groups are kept alive for an additional 14 days without treatment to detect possible delayed toxic effects and to follow up recovery[3].

Mice: Sterile aqueous solutions of moniliformin are injected intraperitoneally (0.2 mL) into five female and five male white mice, weighing about 25 g each, at concentrations equivalent to 0, 20, 25, 30, and 35 mg per kg of body weight. The mice are observed over a 4-day period, and LD50 values are determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Moniliformin sodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 8.3306 mL 41.6528 mL 83.3056 mL 208.2639 mL
5 mM 1.6661 mL 8.3306 mL 16.6611 mL 41.6528 mL
10 mM 0.8331 mL 4.1653 mL 8.3306 mL 20.8264 mL
15 mM 0.5554 mL 2.7769 mL 5.5537 mL 13.8843 mL
20 mM 0.4165 mL 2.0826 mL 4.1653 mL 10.4132 mL
25 mM 0.3332 mL 1.6661 mL 3.3322 mL 8.3306 mL
30 mM 0.2777 mL 1.3884 mL 2.7769 mL 6.9421 mL
40 mM 0.2083 mL 1.0413 mL 2.0826 mL 5.2066 mL
50 mM 0.1666 mL 0.8331 mL 1.6661 mL 4.1653 mL
60 mM 0.1388 mL 0.6942 mL 1.3884 mL 3.4711 mL
80 mM 0.1041 mL 0.5207 mL 1.0413 mL 2.6033 mL
100 mM 0.0833 mL 0.4165 mL 0.8331 mL 2.0826 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moniliformin71376-34-6串珠镰刀菌素钠盐FungalAntibioticInhibitorinhibitorinhibit

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