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NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 Ki 值为70 nM。

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NBTGR Chemical Structure

NBTGR Chemical Structure

CAS No. : 13153-27-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1870
In-stock
1 mg ￥772
In-stock
5 mg ￥1700
In-stock
10 mg ￥2700
In-stock
25 mg ￥5400
In-stock
50 mg ￥7800
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

NBTGR 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM.

IC50 & Target

Ki: 70 nM (adenosine uptake)[1]
体外研究
(In Vitro)

A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NBTGR 相关抗体:
分子量

434.43

Formula

C17H18N6O6S
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (230.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3019 mL 11.5093 mL 23.0187 mL
5 mM 0.4604 mL 2.3019 mL 4.6037 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.13%

COA (265 KB) LCMS (476 KB)

产品使用指南 (1538 KB)
参考文献

NBTGR 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3019 mL 11.5093 mL 23.0187 mL 57.5467 mL
5 mM 0.4604 mL 2.3019 mL 4.6037 mL 11.5093 mL
10 mM 0.2302 mL 1.1509 mL 2.3019 mL 5.7547 mL
15 mM 0.1535 mL 0.7673 mL 1.5346 mL 3.8364 mL
20 mM 0.1151 mL 0.5755 mL 1.1509 mL 2.8773 mL
25 mM 0.0921 mL 0.4604 mL 0.9207 mL 2.3019 mL
30 mM 0.0767 mL 0.3836 mL 0.7673 mL 1.9182 mL
40 mM 0.0575 mL 0.2877 mL 0.5755 mL 1.4387 mL
50 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1509 mL
60 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9591 mL
80 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7193 mL
100 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5755 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBTGR13153-27-0OthersInhibitorinhibitorinhibit

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产品名称：
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目录号：
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