2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. NCI172112

NCI172112  (Synonyms: NSC172112; NSC268497)

目录号: HY-U00155 纯度: 99.08%
COA 产品使用指南

摩尔计算器

NCI172112 是一种经典的双功能烷化剂，是为了开发有效抗中枢神经系统肿瘤而合成的一种抗肿瘤剂。

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NCI172112 Chemical Structure

NCI172112 Chemical Structure

CAS No. : 56605-16-4

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥8400
In-stock
10 mg   询价  
50 mg   询价  

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NCI172112 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

体内研究
(In Vivo)

NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier[1]. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U-14C]NCI172112 or [hydantoin-4-14C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin-14C]NCI172112 than with [ethyl-14C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin-14C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin-14C]NCI172112 and less than 1% is measured after administration of [ethyl-14C]NCI172112. Renal clearance of radioactivity is similar 4 h after administration of [14C]NCI172112 to rats with biliary cannulas, with 14.1±2.9 and 17.5±2.1% of the ethyl-14C and 34.5±2.5 and 33.1±6.3%, of the hydantoin-14C dose appearing in the urine after dosing with 3.13 and 6.25 mg/kg, respectively. A difference in the 4 h urinary excretion of the two labels also is observed in dogs given [14C]NCI172112 (1 mg/kg, i.v.). The percentages of hydantoin-14C and ethyl-14C eliminated are 29.4±2.7% and 17.2±3.5%, respectively (P<0.05)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

336.26

Formula

C14H23Cl2N3O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (297.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9739 mL 14.8694 mL 29.7389 mL
5 mM 0.5948 mL 2.9739 mL 5.9478 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.08%

COA (263 KB) HNMR (344 KB) RP-HPLC (364 KB) LCMS (104 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[2]

Rats[2]
Male Sprague-Dawley rats (190-240 g) are lightly anaesthetized with pentobarbital (30 mg/kg i.p.) and [14C]NCI172112 (2 μCi/rat, 3.13 mg/kg) dissolved in DMSO injected into the femoral vein. The animals are individually housed in glass metabolic cages, with access to food and water for 96 h, and urine and faeces are collected separately. At 96 h, the rats are killed with an overdose of pentobarbital and each carcass is homogenized in 4 vol. water with a Waring blender. Radioactivity in aliquots of drug soln. and urine are measured by liquid scintillation counting with 15 mL phosphor.
Dogs[2]
Female foxhounds, weighing 15-20 kg, are anaesthetized with pentobarbital (30 mg/kg) and are maintained in this state throughout the experiment with aditional pentobarbital. [14C] NCI172112 (50-60 μCi, 1 mg/kg) in 1 mL DMSO is administered to the dogs via a catheter inserted into the femoral vein. Blood samples are withdrawn from the femoral artery by means of an indwelling catheter at timed intervals from 1 min to 4 h and transferred to heparinized tubes chilled on crushed ice. Immediately, a 0.5 mL aliquot is removed and extracted with three 2 mL vol. of cold toluene. The remaining blood is centrifuged, and 0.5 mL aliquots of plasma digested with NCS, extracted with 2 mL vol. of toluene or diluted with 2 mL 10% trichloroacetic acid. From the initial sampling of the dog blood to the start of the extraction or pptn. procedures for plasma, 8-14 min elapsed.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

NCI172112 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9739 mL 14.8694 mL 29.7389 mL 74.3472 mL
5 mM 0.5948 mL 2.9739 mL 5.9478 mL 14.8694 mL
10 mM 0.2974 mL 1.4869 mL 2.9739 mL 7.4347 mL
15 mM 0.1983 mL 0.9913 mL 1.9826 mL 4.9565 mL
20 mM 0.1487 mL 0.7435 mL 1.4869 mL 3.7174 mL
25 mM 0.1190 mL 0.5948 mL 1.1896 mL 2.9739 mL
30 mM 0.0991 mL 0.4956 mL 0.9913 mL 2.4782 mL
40 mM 0.0743 mL 0.3717 mL 0.7435 mL 1.8587 mL
50 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4869 mL
60 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2391 mL
80 mM 0.0372 mL 0.1859 mL 0.3717 mL 0.9293 mL
100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.7435 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCI17211256605-16-4NSC172112 NSC268497NCI 172112NCI-172112NSC 172112NSC-172112NSC268497NSC 268497NSC-268497DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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