1. Metabolic Enzyme/Protease
  2. Aminopeptidase

NGR peptide Trifluoroacetate (Synonyms: CNGRCG Trifluoroacetate)

目录号: HY-P1043A 纯度: 98.55%
Data Sheet SDS 产品使用指南

NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。

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NGR peptide Trifluoroacetate Chemical Structure

NGR peptide Trifluoroacetate Chemical Structure

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Size Price Stock Quantity
10 mM * 1 mL in Water ¥4770 In-stock
1 mg ¥1000 In-stock
5 mg ¥3000 In-stock
10 mg   Get quote  
50 mg   Get quote  

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Description

NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.

IC50 & Target

CD13/aminopeptidase N (APN) receptor[1]

In Vitro

NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself[2].

In Vivo

NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy[2].

References
Molecular Weight

722.72

Formula

C₂₂H₃₇F₃N₁₀O₁₀S₂

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 100 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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产品名称:
NGR peptide Trifluoroacetate
目录号:
HY-P1043A
需求量: