1. Stem Cell/Wnt
  2. β-catenin

NRX-252262 

目录号: HY-111760
产品使用指南

NRX-252262 是一种有效的 β-Catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂,能够促进 β-catenin 的降解,EC50 值为 3.8 nM。

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NRX-252262 Chemical Structure

NRX-252262 Chemical Structure

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Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCFβ-TrCP)[1]

In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

References
Molecular Weight

545.36

Formula

C₂₃H₁₇Cl₂F₃N₂O₄S

SMILES

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
NRX-252262
目录号:
HY-111760
需求量:

NRX-252262

Cat. No.: HY-111760