2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. NS-638

NS-638是具有阻断Ca2+-离子通道性质的非肽类小分子。细胞内阻断由K+激活的Ca2+浓度升高的IC50值为3.4 μM。

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NS-638 Chemical Structure

NS-638 Chemical Structure

CAS No. : 150493-34-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥896
In-stock
2 mg ￥500
In-stock
5 mg ￥940
In-stock
10 mg ￥1400
In-stock
25 mg ￥2900
In-stock
50 mg ￥4700
In-stock
100 mg ￥6400
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

NS-638 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.

IC50 & Target

IC50: 3.4 μM (K+-stimulated intracellular Ca2+-elevation) [1]
体外研究
(In Vitro)

NS-638 dose dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 μM, respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked with an IC50 value of 3.4 μM. At this concentration no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NS-638 相关抗体:
体内研究
(In Vivo)

In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

325.72

Formula

C15H11ClF3N3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 34 mg/mL (104.38 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0701 mL 15.3506 mL 30.7012 mL
5 mM 0.6140 mL 3.0701 mL 6.1402 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice: In the mouse middle cerebral artery occlusion model, NS-638 is administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

NS-638 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0701 mL 15.3506 mL 30.7012 mL 76.7530 mL
5 mM 0.6140 mL 3.0701 mL 6.1402 mL 15.3506 mL
10 mM 0.3070 mL 1.5351 mL 3.0701 mL 7.6753 mL
15 mM 0.2047 mL 1.0234 mL 2.0467 mL 5.1169 mL
20 mM 0.1535 mL 0.7675 mL 1.5351 mL 3.8377 mL
25 mM 0.1228 mL 0.6140 mL 1.2280 mL 3.0701 mL
30 mM 0.1023 mL 0.5117 mL 1.0234 mL 2.5584 mL
40 mM 0.0768 mL 0.3838 mL 0.7675 mL 1.9188 mL
50 mM 0.0614 mL 0.3070 mL 0.6140 mL 1.5351 mL
60 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
80 mM 0.0384 mL 0.1919 mL 0.3838 mL 0.9594 mL
100 mM 0.0307 mL 0.1535 mL 0.3070 mL 0.7675 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS-638150493-34-8NS638NS 638Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-101428
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