1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Epigenetics
  2. EGFR
    Histone Acetyltransferase
    Epigenetic Reader Domain
  3. NSC 228155

NSC 228155 

目录号: HY-101084 纯度: >98.0%
产品使用指南

NSC 228155 为 EGFR 激活剂,可与 EGFR 的胞外区域结合,诱导 EGFR 的磷酸化。NSC 228155 是一种有效的 KIX-KID 相互作用抑制剂,能够抑制 CREB 的激酶诱导结构域 (KID) 和 KIX (KID 相互作用结构域,来自 CBP) 的相互作用,IC50 值为 0.36 μM。

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NSC 228155 Chemical Structure

NSC 228155 Chemical Structure

CAS No. : 113104-25-9

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥55 In-stock
5 mg ¥500 In-stock
10 mg ¥700 In-stock
50 mg ¥2800 In-stock
100 mg ¥4900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].

IC50 & Target

EGFR

 

KIX-KID

0.36 μM (IC50)

In Vitro

NSC 228155 (100 μM) enhances EGFR tyrosine phosphorylation via action of SOD1[1].
NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC50s of 2.09 and 6.14 μM, respectively[2].
NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16 mg/mL (55.12 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4453 mL 17.2265 mL 34.4531 mL
5 mM 0.6891 mL 3.4453 mL 6.8906 mL
10 mM 0.3445 mL 1.7227 mL 3.4453 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 1.6 mg/mL (5.51 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

290.25

Formula

C₁₁H₆N₄O₄S

CAS No.

113104-25-9

SMILES

[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
NSC 228155
目录号:
HY-101084
需求量:

NSC 228155

Cat. No.: HY-101084