1. Epigenetics
  2. Histone Acetyltransferase
    Epigenetic Reader Domain

NSC 228155 

目录号: HY-101084 纯度: >98.0%
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NSC 228155 是一种有效的 KIX-KID 相互作用抑制剂,能够抑制 CREB 的激酶诱导结构域 (KID) 和 KIX (KID 相互作用结构域,来自 CBP) 的相互作用,IC50 值为 0.36 μM。在活的 HEK 293T 细胞中,NSC 228155 对 CREB 介导的基因转录的抑制作用并非选择性的。

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NSC 228155 Chemical Structure

NSC 228155 Chemical Structure

CAS No. : 113104-25-9

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Description

NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].

IC50 & Target

IC50: 0.36 μM (KIX-KID)[1]

In Vitro

NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with IC50s of 2.09 and 6.14 μM, respectively[1].

References
Molecular Weight

290.25

Formula

C₁₁H₆N₄O₄S

CAS No.

113104-25-9

SMILES

[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
NSC 228155
目录号:
HY-101084
需求量:

NSC 228155

Cat. No.: HY-101084