1. 天然产物
  2. Alkaloid

Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. This group also includes some related compounds with neutral and even weakly acidic properties. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. Alkaloids have a wide range of pharmacological activities including antimalarial, antiasthma, anticancer, cholinomimetic, vasodilatory, antiarrhythmic, analgesic, antibacterial, and antihyperglycemic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic and stimulant activities, and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too. Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.

Alkaloid (187):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12526
    Tetrodotoxin 4368-28-9 99.99%
    Tetrodotoxin 是一种选择性的钠离子通道 (sodium channel) 抑制剂,作用于 Nav1.6IC50 为 33 nM。
    Tetrodotoxin
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.40%
    Vincristine sulfate 是一种微管聚合抑制剂,能够与微管蛋白结合,IC50 值为 32 μM。
    Vincristine sulfate
  • HY-10448
    Capsaicin 404-86-4 >98.0%
    Capsaicin 是一种 TRPV1 激动剂,作用 HEK293 细胞,EC50 为 0.29±0.05 μM。
    Capsaicin
  • HY-16569
    Colchicine 64-86-8 99.56%
    Colchicine 是一种 tubulin 抑制剂及微管 microtubule干扰剂。Colchicine诱导细胞凋亡。
    Colchicine
  • HY-10820A
    Pemetrexed disodium 150399-23-8 99.04%
    Pemetrexed disodium 是一种叶酸拮抗剂 (antifolate)。
    Pemetrexed disodium
  • HY-14944
    Homoharringtonine 26833-87-4
    Homoharringtonine 是一种细胞毒性生物碱,作用于抗 Gefitinib 的肺癌细胞,诱导细胞凋亡,且通过 IL-6/JAK1/STAT3 信号通路来抑制 STAT3
    Homoharringtonine
  • HY-16563
    Narciclasine 29477-83-6 99.94%
    Narciclasine 是一种植物生长调节剂。Narciclasine 调节Rho/Rho激酶/LIM激酶/cofilin信号通路,大大增加GTPase RhoA活性,以及诱导肌动蛋白应激纤维形成,这种作用存在RhoA依赖性。
    Narciclasine
  • HY-12048
    Chelerythrine Chloride 3895-92-9 >98.0%
    Chelerythrine Chloride 是一种有效的,细胞穿透的蛋白酶 C (protein kinase C) 和 促分裂原活化蛋白激酶 (MAPK) 抑制剂,能够抑制 PKC 活性,IC50 值为 660 nM。
    Chelerythrine Chloride
  • HY-B0638
    L-Nicotine 54-11-5 99.96%
    L-Nicotine是原型烟酸乙酰胆碱受体激动剂;天然异构体。
    L-Nicotine
  • HY-N0086
    N6-Methyladenosine 1867-73-8 99.51%
    N6-Methyladenosine 是存在于所有高等真核生物中最普遍的的信使 RNA (mRNA) 内部 (非帽) 修饰。
    N6-Methyladenosine
  • HY-10572
    Efavirenz 154598-52-4 99.69%
    Efavirenz 是一种有效的野生型 HIV-1 RT 抑制剂,Ki 为 2.93 nM,抑制 HIV-1 复制,IC95 为 1.5 nM。
    Efavirenz
  • HY-B0282
    Acetylcholine chloride 60-31-1 >98.0%
    Acetylcholine是神经递质,能诱导钙离子通道开放。
    Acetylcholine chloride
  • HY-N0296A
    Scopolamine hydrobromide 114-49-8 >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
    Scopolamine hydrobromide
  • HY-B0345A
    ATP disodium salt 987-65-5 98.47%
    ATP二钠盐是P2嘌呤受体激动剂。
    ATP disodium salt
  • HY-N0737A
    Harmine 442-51-3 99.58%
    去氢骆驼蓬碱 (Harmine) 是一种天然生物碱,分离自骆驼蓬种子,常用于抗焦虑研究。
    Harmine
  • HY-N0127
    Yohimbine Hydrochloride 65-19-0 99.79%
    Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
    Yohimbine Hydrochloride
  • HY-B0809
    Theophylline 58-55-9 99.58%
    Theophylline是甲基黄嘌呤衍生物,竞争性非选择性磷酸二酯酶抑制剂和非选择性腺苷受体拮抗剂。
    Theophylline
  • HY-N0219
    (+)-Bicuculline 485-49-4 99.92%
    比枯枯灵 (Bicucullin),一种生物碱,是GABA的拮抗剂。
    (+)-Bicuculline
  • HY-N0095
    (S)-10-Hydroxycamptothecin 19685-09-7 99.20%
    (S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。
    (S)-10-Hydroxycamptothecin
  • HY-N0304
    L-DOPA 59-92-7 99.72%
    L-DOPA是DOPA的天然形式,是多巴胺前体,可作用于帕金森氏病。
    L-DOPA