1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

O-304 

目录号: HY-112233 纯度: 98.63%
产品使用指南

O-304是一种小分子 AMPK 激活剂。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

O-304 Chemical Structure

O-304 Chemical Structure

CAS No. : 1261289-04-6

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1980 In-stock
5 mg ¥1800 In-stock
10 mg ¥2800 In-stock
25 mg ¥5500 In-stock
50 mg ¥8500 In-stock
100 mg ¥13000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

O-304 is a small molecule AMPK activator.

IC50 & Target

AMPK[1]

In Vivo

O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an “Exercise mimetic”. Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease[1].

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (78.90 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6298 mL 13.1492 mL 26.2985 mL
5 mM 0.5260 mL 2.6298 mL 5.2597 mL
10 mM 0.2630 mL 1.3149 mL 2.6298 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

380.25

Formula

C₁₆H₁₁Cl₂N₃O₂S

CAS No.

1261289-04-6

SMILES

O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
O-304
目录号:
HY-112233
需求量:

O-304

Cat. No.: HY-112233