1. PI3K/Akt/mTOR
  2. PI3K

PI3Kγ inhibitor 3 

目录号: HY-112443
产品使用指南

PI3Kγ inhibitor 3 是一种有效的选择性 PI3Kγ 抑制剂,抑制 PI3Kγ, PI3Kα, PI3Kβ, 和 PI3KδpIC50 分别为 9.1, 5.1, <4.5, 和 6.5。

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PI3Kγ inhibitor 3 Chemical Structure

PI3Kγ inhibitor 3 Chemical Structure

CAS No. : 2132961-46-5

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Description

PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

IC50 & Target[1]

PI3Kγ

9.1 (pIC50)

PI3Kα

5.1 (pIC50)

PI3Kβ

4.5 (pIC50)

PI3Kδ

6.5 (pIC50)

PI3KC2α

5 (pIC50)

PI3KC2β

7.5 (pIC50)

PI3KC2γ

5.5 (pIC50)

PI3KC3

5.1 (pIC50)

In Vitro

PI3Kγ inhibitor 3 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].

References
Molecular Weight

433.54

Formula

C₂₀H₂₃N₃O₄S₂

CAS No.

2132961-46-5

SMILES

O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PI3Kγ inhibitor 3
目录号:
HY-112443
需求量:

PI3Kγ inhibitor 3

Cat. No.: HY-112443