1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. Pipequaline

Pipequaline  (Synonyms: PK-8165)

目录号: HY-100140 纯度: 99.77%
COA 产品使用指南

Pipequaline (PK 8165) 是一种苯二氮卓受体部分激动剂,具有抗焦虑活性。

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Pipequaline Chemical Structure

Pipequaline Chemical Structure

CAS No. : 77472-98-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1723
In-stock
2 mg ¥435
In-stock
5 mg ¥870
In-stock
10 mg ¥1200
In-stock
50 mg ¥3700
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Other Forms of Pipequaline:

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].

IC50 & Target

Benzodiazepine receptor[1]

体内研究
(In Vivo)

Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

316.44

Formula

C22H24N2

CAS 号
性状

固体

颜色

White to off-white

中文名称

哌夸林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 32 mg/mL (101.13 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1602 mL 15.8008 mL 31.6016 mL
5 mM 0.6320 mL 3.1602 mL 6.3203 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[3]

Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1602 mL 15.8008 mL 31.6016 mL 79.0039 mL
5 mM 0.6320 mL 3.1602 mL 6.3203 mL 15.8008 mL
10 mM 0.3160 mL 1.5801 mL 3.1602 mL 7.9004 mL
15 mM 0.2107 mL 1.0534 mL 2.1068 mL 5.2669 mL
20 mM 0.1580 mL 0.7900 mL 1.5801 mL 3.9502 mL
25 mM 0.1264 mL 0.6320 mL 1.2641 mL 3.1602 mL
30 mM 0.1053 mL 0.5267 mL 1.0534 mL 2.6335 mL
40 mM 0.0790 mL 0.3950 mL 0.7900 mL 1.9751 mL
50 mM 0.0632 mL 0.3160 mL 0.6320 mL 1.5801 mL
60 mM 0.0527 mL 0.2633 mL 0.5267 mL 1.3167 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9875 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7900 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pipequaline
目录号:
HY-100140
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