2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Progabide

Progabide  (Synonyms: 普罗加比; SL 76002)

目录号: HY-A0173 纯度: 99.42%
COA 产品使用指南

摩尔计算器

Progabide 是一种 γ-氨基丁酸 (GABA) 受体激动剂。

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Progabide Chemical Structure

Progabide Chemical Structure

CAS No. : 62666-20-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥660
In-stock
5 mg ￥600
In-stock
10 mg ￥1000
In-stock
25 mg ￥2000
In-stock
50 mg ￥3200
In-stock
100 mg ￥5000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Progabide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.

IC50 & Target

GABA receptor[1]
体内研究
(In Vivo)

Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.77

Formula

C17H16ClFN2O2
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

普罗加比
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (746.78 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9871 mL 14.9356 mL 29.8713 mL
5 mM 0.5974 mL 2.9871 mL 5.9743 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Male Wistar rats weighing 170 to 240 g are caged in groups of three under diurnal lighting conditions with free access to food and water. The rats are accustomed to handling (housing 1 per cage for 30 min, injecting with saline, 1 mL/100 g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80. Control rats are treated IP with the corresponding vehicle (1 mL/100 g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Progabide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9871 mL 14.9356 mL 29.8713 mL 74.6781 mL
5 mM 0.5974 mL 2.9871 mL 5.9743 mL 14.9356 mL
10 mM 0.2987 mL 1.4936 mL 2.9871 mL 7.4678 mL
15 mM 0.1991 mL 0.9957 mL 1.9914 mL 4.9785 mL
20 mM 0.1494 mL 0.7468 mL 1.4936 mL 3.7339 mL
25 mM 0.1195 mL 0.5974 mL 1.1949 mL 2.9871 mL
30 mM 0.0996 mL 0.4979 mL 0.9957 mL 2.4893 mL
40 mM 0.0747 mL 0.3734 mL 0.7468 mL 1.8670 mL
50 mM 0.0597 mL 0.2987 mL 0.5974 mL 1.4936 mL
60 mM 0.0498 mL 0.2489 mL 0.4979 mL 1.2446 mL
80 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9335 mL
100 mM 0.0299 mL 0.1494 mL 0.2987 mL 0.7468 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Progabide62666-20-0SL 76002普罗加比SL76002SL-76002GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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