2. RR-11a

RR-11a是人工合成的天冬酰胺酰内肽酶 Legumain 抑制剂 (IC50=31-55 nM)。RR-11a 可用于癌症和急性心肌梗死 (AMI) 的研究。

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RR-11a Chemical Structure

RR-11a Chemical Structure

CAS No. : 1361390-56-8

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Other Forms of RR-11a:

RR-11a 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI)[1][2][3].

IC50 & Target[2]

Legumain

31-55 nM (IC50)

体外研究
(In Vitro)

Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RR-11a 相关抗体:
体内研究
(In Vivo)

Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
RR-11a (20 mg/kg; daily i.p. for 30 days) improves cardiac function, decreases cardiac rupture rate, and attenuates left chamber dilation and wall thinning post-AMI in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

560.51

Formula

C24H28N6O10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]

Mice bearing 4T1 orthothopic tumors of approximately 500 mm3 are injected once intravenously with RR-11a+ or RR-11a-nanoparticles labeled with rhodamine B. Alternatively, mice are injected intravenously 3 times at 48-hour intervals with RDZ-218, NP-DOX, free DOX, or saline. Twenty-four hours after the final treatment, animals are sacrificed and spleen, kidney, lungs, liver, heart and tumor are collected, frozen in OCT compound, immediately sectioned and imaged by fluorescence microscopy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RR-11a1361390-56-8micecanceracute myocardial infarctioncardiac functionsyntheticInhibitorinhibitorinhibit

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产品名称：
RR-11a
目录号：
HY-112205
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