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  2. Reactive Oxygen Species
  3. Riboflavin Tetrabutyrate

Riboflavin Tetrabutyrate  (Synonyms: 核黄素四丁酸酯;四丁酸核糖黄素酯)

目录号: HY-B2239 纯度: 98.93%
COA 产品使用指南

Riboflavin Tetrabutyrate 是具有抗氧化和脂质过氧化物去除活性的亲脂性黄素衍生物。

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Riboflavin Tetrabutyrate Chemical Structure

Riboflavin Tetrabutyrate Chemical Structure

CAS No. : 752-56-7

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10 mM * 1 mL in DMSO ¥550
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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

体外研究
(In Vitro)

Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid[1]. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

656.72

Formula

C33H44N4O10

CAS 号
性状

固体

颜色

Yellow to orange

中文名称

核黄素四丁酸酯;四丁酸核糖黄素酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (152.27 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5227 mL 7.6136 mL 15.2272 mL
5 mM 0.3045 mL 1.5227 mL 3.0454 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[3]

Rats: Riboflavin tetrabutyrate-14C (700 μg, corresponding to 400 μg of riboflavin; total radioactivity 2.19×105 cpm) is suspended in 0.2mL of soybean oil and given per os . In the case of injection, same amount of Riboflavin tetrabutyrate-14C is dissolved in 1mL of soybean oil and injected subcutaneously into the back of rat[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5227 mL 7.6136 mL 15.2272 mL 38.0680 mL
5 mM 0.3045 mL 1.5227 mL 3.0454 mL 7.6136 mL
10 mM 0.1523 mL 0.7614 mL 1.5227 mL 3.8068 mL
15 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5379 mL
20 mM 0.0761 mL 0.3807 mL 0.7614 mL 1.9034 mL
25 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL
30 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
40 mM 0.0381 mL 0.1903 mL 0.3807 mL 0.9517 mL
50 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.7614 mL
60 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
80 mM 0.0190 mL 0.0952 mL 0.1903 mL 0.4758 mL
100 mM 0.0152 mL 0.0761 mL 0.1523 mL 0.3807 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
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目录号:
HY-B2239
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