1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. SAR125844

SAR125844 

目录号: HY-16446 纯度: 99.03%
产品使用指南

SAR125844 是一种有效的、高度选择性的、可逆的、ATP竞争性的 MET受体酪氨酸激酶 (RTK) 的抑制剂,其IC50 值为4.2 nM。能抑制细胞中MET的自磷酸化。

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SAR125844 Chemical Structure

SAR125844 Chemical Structure

CAS No. : 1116743-46-4

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥145 In-stock
5 mg ¥1100 In-stock
10 mg ¥1800 In-stock
50 mg ¥7300 In-stock
100 mg ¥12000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays[1].

IC50 & Target

IC50: 4.2 nM (MET RTK)[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 45 mg/mL (81.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8161 mL 9.0805 mL 18.1610 mL
5 mM 0.3632 mL 1.8161 mL 3.6322 mL
10 mM 0.1816 mL 0.9081 mL 1.8161 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.09 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

550.63

Formula

C₂₅H₂₃FN₈O₂S₂

CAS No.

1116743-46-4

SMILES

O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
SAR125844
目录号:
HY-16446
需求量:

SAR125844

Cat. No.: HY-16446