1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. SAR7334

SAR7334 是一种有效的 TRPC6 特异性抑制剂,能够抑制 TRPC6 电流,IC50 值为 7.9 nM。

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SAR7334 Chemical Structure

SAR7334 Chemical Structure

CAS No. : 1333210-07-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2200
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1 mg ¥909
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5 mg ¥2000
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10 mg ¥3200
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50 mg ¥5900
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100 mg ¥7500
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Top Publications Citing Use of Products

    SAR7334 purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015.  [Abstract]

    HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.

    查看 TRP Channel 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

    IC50 & Target

    IC50: 7.9 nM (TRPC6 currents)[3]

    体外研究
    (In Vitro)

    SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1]. SAR7334 (1 μM) has negligible effect on SOCE[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    367.87

    Formula

    C21H22ClN3O

    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : ≥ 370 mg/mL (1005.79 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.7184 mL 13.5918 mL 27.1835 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.88%

    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7184 mL 13.5918 mL 27.1835 mL 67.9588 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL 13.5918 mL
    10 mM 0.2718 mL 1.3592 mL 2.7184 mL 6.7959 mL
    15 mM 0.1812 mL 0.9061 mL 1.8122 mL 4.5306 mL
    20 mM 0.1359 mL 0.6796 mL 1.3592 mL 3.3979 mL
    25 mM 0.1087 mL 0.5437 mL 1.0873 mL 2.7184 mL
    30 mM 0.0906 mL 0.4531 mL 0.9061 mL 2.2653 mL
    40 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6990 mL
    50 mM 0.0544 mL 0.2718 mL 0.5437 mL 1.3592 mL
    60 mM 0.0453 mL 0.2265 mL 0.4531 mL 1.1326 mL
    80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8495 mL
    100 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6796 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    SAR7334
    目录号:
    HY-15699
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