1. Metabolic Enzyme/Protease
  2. Phosphatase

SHIP2-IN-1 

目录号: HY-112700
产品使用指南

SHIP2-IN-1 是一种有效的 SHIP2 抑制剂,IC50 值为 2 µM。SHIP2-IN-1 可使 GSK3β 的 Ser9 位点磷酸化,抑制 GSK3β 的活化。SHIP2-IN-1 可用于阿尔滋海默症的研究。

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SHIP2-IN-1 Chemical Structure

SHIP2-IN-1 Chemical Structure

CAS No. : 2252247-80-4

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Description

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

IC50 & Target

IC50: 2 µM (SHIP2)[1]

In Vitro

SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].

References
Molecular Weight

379.22

Formula

C₁₇H₁₃Cl₂FN₄O

CAS No.

2252247-80-4

SMILES

FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
SHIP2-IN-1
目录号:
HY-112700
需求量:

SHIP2-IN-1

Cat. No.: HY-112700