1. Epigenetics Apoptosis
  2. MicroRNA Apoptosis
  3. SID 3712249

SID 3712249  (Synonyms: MiR-544 Inhibitor 1)

目录号: HY-19731 纯度: 99.91%
COA 产品使用指南

SID 3712249 (MiR-544 Inhibitor 1) 是一种 miR-544 生物合成抑制剂。SID 3712249 直接与前体 miRNA 结合。SID 3712249 阻断成熟 microRNA 的产生并减少 miR-544、HIF-1α 和 ATM 转录物。SID 3712249 可用于癌症研究。

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SID 3712249 Chemical Structure

SID 3712249 Chemical Structure

CAS No. : 522606-67-3

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Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥935
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5 mg ¥850
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10 mg ¥1450
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25 mg ¥3100
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50 mg ¥4950
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100 mg ¥7950
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer[1].

IC50 & Target

MiR-544[1]

体外研究
(In Vitro)

SID 3712249 (compound 1, 20 nM, 48 h) disrupts miR-544-mediated inhibition of BMI1 based on significant increases in the RFP/BFP ratio[1].
SID 3712249 (20 nM, 48 h) inhibits precursor but not mature miR-544 binding to BMI1 or mTOR3’-UTR[1].
SID 3712249 (20 nM, 48 h) results in accumulation of pre-miR-544 and a decrease in miR-544 levels in MCF10A cells[1].
SID 3712249 (20 nM, 5 days) induces apoptosis in MDA-MB-231 and MCF- 7 cells and has no effect on cell survival in normoxic conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231, MCF-7 cells
Concentration: 20 nM
Incubation Time: 5 days
Result: Induced apoptosis and has no effect on cell survival in normoxic conditions (flow cytometric analysis of Annexin V and PI stainning).
体内研究
(In Vivo)

SID 3712249 (compound 1, 100 μL of 40 μM, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model[1].
SID 3712249 (20 nM, pre-treated GFP-labeled MDA-MB-231 cells, intraperitoneal injection) inhibited tumor growth in MDA-MB-231-GFP-luc tumor model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-MB-231-GFP-luc tumor model[1]
Dosage: 100 μL of 40 μM
Administration: Intraperitoneal injection
Result: Inhibited tumor growth (evidenced by live animal bioluminescent imaging) with no overt side effects.
Decreased levels of miR-544, ATM, and HIF-1α and increased levels of mTOR (resected tumor samples).
分子量

323.40

Formula

C17H21N7

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 16.67 mg/mL (51.55 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0921 mL 15.4607 mL 30.9215 mL
5 mM 0.6184 mL 3.0921 mL 6.1843 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.91%

参考文献

SID 3712249 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0921 mL 15.4607 mL 30.9215 mL 77.3037 mL
5 mM 0.6184 mL 3.0921 mL 6.1843 mL 15.4607 mL
10 mM 0.3092 mL 1.5461 mL 3.0921 mL 7.7304 mL
15 mM 0.2061 mL 1.0307 mL 2.0614 mL 5.1536 mL
20 mM 0.1546 mL 0.7730 mL 1.5461 mL 3.8652 mL
25 mM 0.1237 mL 0.6184 mL 1.2369 mL 3.0921 mL
30 mM 0.1031 mL 0.5154 mL 1.0307 mL 2.5768 mL
40 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9326 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.5461 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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