2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. SNT-207858

SNT-207858 是一种选择性，可渗透血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 抑制与 MC-4 受体结合，IC50 为 22 nM。SNT-207858 抑制 MC-4 活性，IC50 为 11 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

SNT-207858 Chemical Structure

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

SNT-207858 的其他形式现货产品:

Customer Review

Other Forms of SNT-207858:

SNT-207858 相关抗体

注册 MCE会员 并 完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50 & Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]
体外研究
(In Vitro)

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNT-207858 相关抗体:
体内研究
(In Vivo)

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 15 days
Result: Significantly reduced the tumor induced weight loss.
分子量

689.54

Formula

C32H45Cl4N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNT-207858 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNT-2078581104080-42-3SNT207858SNT 207858Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
SNT-207858
目录号：
HY-11030
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z