1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

SR-4370 

目录号: HY-111400 纯度: 98.33%
产品使用指南

SR-4370 是一种有效的 HDAC 抑制剂,对 HDAC1,HDAC2,HDAC3,HDAC8 和 HDAC6 的 IC50 值分别为 0.13 μM,0.58 μM,0.006 μM,2.3 μM 和 3.4 μM。

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SR-4370 Chemical Structure

SR-4370 Chemical Structure

CAS No. : 1816294-67-3

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1760 In-stock
5 mg ¥1600 In-stock
10 mg ¥2700 In-stock
50 mg ¥9500 In-stock
100 mg ¥15000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

IC50 & Target[1]

HDAC3

6 nM (IC50)

HDAC1

130 nM (IC50)

HDAC2

580 nM (IC50)

HDAC8

2300 nM (IC50)

HDAC6

3400 nM (IC50)

In Vitro

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.2859 mL 16.4295 mL 32.8591 mL
5 mM 0.6572 mL 3.2859 mL 6.5718 mL
10 mM 0.3286 mL 1.6430 mL 3.2859 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

304.33

Formula

C₁₇H₁₈F₂N₂O

CAS No.

1816294-67-3

SMILES

O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 150 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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产品名称:
SR-4370
目录号:
HY-111400
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