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SR121566A 是一种新型的非肽 Glycoprotein IIb/IIIa (GP IIb-IIIa) 拮抗剂,可以抑制 ADP,花生四烯酸和胶原诱导的人血小板集合,IC50s 分别为 46±7.5,56±6 和 42±3 nM。

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SR121566A Chemical Structure

SR121566A Chemical Structure

CAS No. : 180144-61-0

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  • 生物活性

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  • 参考文献

生物活性

SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.

IC50 & Target

GP IIb-IIIa[1]

体内研究
(In Vivo)

SR121566A leads to dose-dependent increases in TTO, a statistically significant increase being observed at the doses of 0.3 mg/kg (473%) and 30 mg/kg (771%), respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

431.51

Formula

C20H25N5O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
Animal Administration
[2]

Male mice (26-30 g) are anesthetized, artificially ventilated, and placed on a heated jacket to control body temperature. A femoral vein is cannulated for i.v. injections. In thrombosis experiments, drugs including SR121566A are administered in 0.9% saline for intravenous studies (0.1 mL/30 g, 5 min before stimulation) and in water for oral studies (0.1 mL/30 g, 120 min before stimulation)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

SR121566A 相关分类

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SR121566A
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HY-U00235
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