1. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  2. LXR
  3. SR9243

SR9243 是 liver-X-receptor (LXR) 的反向激动剂,能够诱导 LXR-辅阻遏物相互作用。

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SR9243 Chemical Structure

SR9243 Chemical Structure

CAS No. : 1613028-81-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥758
In-stock
1 mg ¥250
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5 mg ¥550
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10 mg ¥790
In-stock
50 mg ¥2420
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100 mg ¥4110
In-stock
200 mg ¥6520
In-stock
500 mg   询价  
1 g   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.

体外研究
(In Vitro)

SR9243 特异性靶向 LXR 并下调 LXR 介导的基因表达,在纳摩尔浓度下以剂量依赖性方式抑制 LXRα 和 LXRβ 依赖性转录,并在培养的癌细胞中有效抑制 LXR 驱动的荧光素酶活性。SR9243 抑制前列腺 (PC3,DU-145)、结直肠 (SW620 和 HT29) 和肺 (HOP-62 和NCI-H23) 癌细胞系的细胞活力。癌细胞的集落形成能力也被 SR9243 以剂量依赖的方式显著降低。
SR9243 是一种有效的脂肪生成基因表达抑制剂,可通过消耗细胞内脂质选择性地杀死癌细胞。癌细胞培养基与油酸盐、硬脂酸盐和棕榈酸盐的组合完全挽救了癌细胞中的癌细胞活力。补充脂肪酸还可以挽救糖酵解被显著破坏的 SW620 细胞的活力[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SR9243 能够显著抑制肿瘤糖酵解、脂肪生成并诱导凋亡性癌细胞死亡,而不会促进体内体重减轻。SR9243 在不显著抑制糖酵解基因表达的情况下抑制肿瘤生长,在体内抑制肿瘤生长和脂肪生成而无肝毒性或炎症[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

626.62

Formula

C31H32BrNO4S2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 20 mg/mL (31.92 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5959 mL 7.9793 mL 15.9586 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.88%

参考文献
Cell Assay
[1]

Cancer cells are plated at low-density (5×103) cells per well. Cells are then treated with either DMSO vehicle control, SR9243 (100 nM) or SR9243 (10 μM) and allowed to grow for 4 days. Colonies are then fixed with Formaldehyde (1%) and stained with Crystal violet solution (0.05% w/v)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice[1]
C57BL/6J, Nu/Nu and Ob/Ob mice are used in the assay. Mice are housed in sterile ventilated cages, fed a standard diet, and provided water ad libitum. Mice are treated after two weeks of acclimation. Mice are monitored daily for signs of illness, pain, or severe weight loss. All mice are humanely euthanized using CO2 followed by cervical dislocation. For liver lipid content analysis 8-week old male Ob/Ob mice are fed a high fat diet (60% kcal/fat, 20% carbohydrate) for the duration of the experiment and are treated with vehicle or SR9243 for 3 days. Mice are injected (i.p.) with either vehicle (10% DMSO, 10% Tween-80) or SR9243 (30 mg/kg) once daily[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5959 mL 7.9793 mL 15.9586 mL 39.8966 mL
5 mM 0.3192 mL 1.5959 mL 3.1917 mL 7.9793 mL
10 mM 0.1596 mL 0.7979 mL 1.5959 mL 3.9897 mL
15 mM 0.1064 mL 0.5320 mL 1.0639 mL 2.6598 mL
20 mM 0.0798 mL 0.3990 mL 0.7979 mL 1.9948 mL
25 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5959 mL
30 mM 0.0532 mL 0.2660 mL 0.5320 mL 1.3299 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SR9243
目录号:
HY-16972
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