2. Cell Cycle/DNA Damage Epigenetics Autophagy Apoptosis Metabolic Enzyme/Protease
  3. HDAC Autophagy Apoptosis Endogenous Metabolite
  4. Sodium butyrate

Sodium butyrate  (Synonyms: 丁酸钠; Butanoic acid sodium; Butyric acid sodium)

目录号: HY-B0350A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Sodium Butyrate (Butanoic acid sodium salt) 是一种短链脂肪酸，可以抑制组蛋白去乙酰化酶。

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Sodium butyrate Chemical Structure

Sodium butyrate Chemical Structure

CAS No. : 156-54-7

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规格 价格 是否有货 数量
500 mg ￥300
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1 g ￥350
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5 g ￥650
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Customer Review

Other Forms of Sodium butyrate:

Sodium butyrate 相关抗体

Top Publications Citing Use of Products

    Sodium butyrate purchased from MCE. Usage Cited in: Neurobiol Dis. 2017 Dec 14;111:12-25.  [Abstract]

    Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sodium Butyrate (Butanoic acid sodium salt) is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

    IC50 & Target[2]

    HDAC

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    体外研究
    (In Vitro)

    Sodium Butyrate induces morphological changes, inhibits cell proliferation and impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- and time-dependent decrease in cell viability, in both 5-8F and 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition and disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate[1]. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR and PCNA protein. Sodium butyrate, in a dose-dependent manner, induces cell cycle arrest in G0/G1 phase and reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, and pro-apoptosis bak genes, and protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, and Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), and the levels of cyclinD1 and CDK6 are reduced by 5 and 10 mM butyrate[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Sodium butyrate 相关抗体:
    体内研究
    (In Vivo)

    Sodium Butyrate (300 mg/kg, s.c.) administration immediately after HI provided almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate administration results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia[2]. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    110.09

    Formula

    C4H7NaO2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    丁酸钠
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 100 mg/mL (908.35 mM; 超声助溶)

    DMSO 中的溶解度 : 1 mg/mL (9.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 9.0835 mL 45.4174 mL 90.8348 mL
    5 mM 1.8167 mL 9.0835 mL 18.1670 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

    • 方案 一

      Sodium butyrate (SB) is prepared in PBS[5].

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (189 KB) HNMR (147 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 µL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 µL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 µL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Sodium butyrate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 9.0835 mL 45.4174 mL 90.8348 mL 227.0869 mL
    5 mM 1.8167 mL 9.0835 mL 18.1670 mL 45.4174 mL
    H2O 10 mM 0.9083 mL 4.5417 mL 9.0835 mL 22.7087 mL
    15 mM 0.6056 mL 3.0278 mL 6.0557 mL 15.1391 mL
    20 mM 0.4542 mL 2.2709 mL 4.5417 mL 11.3543 mL
    25 mM 0.3633 mL 1.8167 mL 3.6334 mL 9.0835 mL
    30 mM 0.3028 mL 1.5139 mL 3.0278 mL 7.5696 mL
    40 mM 0.2271 mL 1.1354 mL 2.2709 mL 5.6772 mL
    50 mM 0.1817 mL 0.9083 mL 1.8167 mL 4.5417 mL
    60 mM 0.1514 mL 0.7570 mL 1.5139 mL 3.7848 mL
    80 mM 0.1135 mL 0.5677 mL 1.1354 mL 2.8386 mL
    100 mM 0.0908 mL 0.4542 mL 0.9083 mL 2.2709 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sodium butyrate156-54-7Butanoic acidButyric acid丁酸钠HDACAutophagyApoptosisEndogenous MetaboliteHistone deacetylasesInhibitorinhibitorinhibit

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