1. Apoptosis
  2. Apoptosis
  3. Sodium diatrizoate

Sodium diatrizoate  (Synonyms: 泛影酸钠; Diatrizoic acid sodium salt; Sodium amidotrizoate)

目录号: HY-B0926A 纯度: 99.50%
COA 产品使用指南

Sodium diatrizoate (Diatrizoic acid sodium salt) 是一种碘化造影剂,具有对气道进行放射照相成像的潜力。Sodium diatrizoate 通过钙失调诱导线粒体更新和氧化应激,并激活细胞凋亡。

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Sodium diatrizoate Chemical Structure

Sodium diatrizoate Chemical Structure

CAS No. : 737-31-5

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550
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500 mg ¥500
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Sodium diatrizoate:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium[1][2].

体外研究
(In Vitro)

HK-2 cells are exposed to 0-30 mg I/mL Sodium diatrizoate (Diatrizoic acid sodium salt) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

635.90

Formula

C11H8I3N2NaO4

CAS 号
性状

固体

颜色

White to off-white

中文名称

泛影酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (157.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : ≥ 50 mg/mL (78.63 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5726 mL 7.8629 mL 15.7257 mL
5 mM 0.3145 mL 1.5726 mL 3.1451 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 33.33 mg/mL (52.41 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Animal Administration
[1]

Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Sodium diatrizoate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.5726 mL 7.8629 mL 15.7257 mL 39.3144 mL
5 mM 0.3145 mL 1.5726 mL 3.1451 mL 7.8629 mL
10 mM 0.1573 mL 0.7863 mL 1.5726 mL 3.9314 mL
15 mM 0.1048 mL 0.5242 mL 1.0484 mL 2.6210 mL
20 mM 0.0786 mL 0.3931 mL 0.7863 mL 1.9657 mL
25 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5726 mL
30 mM 0.0524 mL 0.2621 mL 0.5242 mL 1.3105 mL
40 mM 0.0393 mL 0.1966 mL 0.3931 mL 0.9829 mL
50 mM 0.0315 mL 0.1573 mL 0.3145 mL 0.7863 mL
60 mM 0.0262 mL 0.1310 mL 0.2621 mL 0.6552 mL
DMSO 80 mM 0.0197 mL 0.0983 mL 0.1966 mL 0.4914 mL
100 mM 0.0157 mL 0.0786 mL 0.1573 mL 0.3931 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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