1. Anti-infection
  2. Bacterial
  3. TBAJ-587

TBAJ-587 

目录号: HY-111747
产品使用指南

TBAJ-587 是一种有效的抗结核药物,在 MABA 和 LORA 实验中抑制 M.tb 菌株 H37Rv 生长 MIC90 分别为 0.006 和 <0.02 μg/mL。TBAJ-587 对 hERG 通道的抑制作用很低,大大减弱了对心脏钾通道蛋白的抑制,这对心脏复极化很重要。

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TBAJ-587 Chemical Structure

TBAJ-587 Chemical Structure

CAS No. : 2252316-16-6

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Description

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1].

IC50 & Target

Anti-tuberculosis[1]

In Vitro

Bedaquiline is a drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability due to its potent inhibition of the cardiac potassium channel protein hERG. TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade. TBAJ-587 inhibits hERG channel with an IC50 of 13 μM[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

614.50

Formula

C₃₀H₃₃BrFN₃O₅

CAS No.

2252316-16-6

SMILES

COC1=C(F)C([C@H](C2=CC3=CC(Br)=CC=C3N=C2OC)[C@](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=CC=C1

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Room temperature in continental US; may vary elsewhere

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产品名称:
TBAJ-587
目录号:
HY-111747
需求量:

TBAJ-587

Cat. No.: HY-111747