1. JAK/STAT Signaling
  2. Pim
  3. TCS PIM-1 1

TCS PIM-1 1  (Synonyms: SC 204330)

目录号: HY-18086 纯度: 98.01%
COA 产品使用指南

TCS PIM-1 1 (SC 204330) 是一种有效的,具有选择性和 ATP 竞争性的 Pim-1 激酶抑制剂,IC50 为 50 nM,对 Pim-2 和 MEK1/MEK2 表现出良好的选择性 (IC50 >20000 nM)。

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TCS PIM-1 1 Chemical Structure

TCS PIM-1 1 Chemical Structure

CAS No. : 491871-58-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1104
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5 mg ¥627
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10 mg ¥1004
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50 mg ¥4371
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200 mg   询价  

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Top Publications Citing Use of Products

    TCS PIM-1 1 purchased from MCE. Usage Cited in: J Cent South Univ. 2018, 43(5): 481-489.

    Effect of Pim-1 inhibitor on expression of T cell transcription factors in mice (n=5) A: Control group; B: TNBS group; C: TNBS+small doses of Pim-1 inhibitor group; D: TNBS+high doses of Pim-1 inhibitor group; E: TNBS+prednisone group.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM)[1].

    IC50 & Target[1]

    PIM1

    50 nM (IC50)

    体外研究
    (In Vitro)

    TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    367.20

    Formula

    C18H11BrN2O2

    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 100 mg/mL (272.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.7233 mL 13.6166 mL 27.2331 mL
    5 mM 0.5447 mL 2.7233 mL 5.4466 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案源自文献,仅供参考,建议您先取少量样品进行尝试。

    • 方案 一

      TCS PIM-1 1 is dissolved in 0.5% DMSO[2].

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    TCS PIM-1 1 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7233 mL 13.6166 mL 27.2331 mL 68.0828 mL
    5 mM 0.5447 mL 2.7233 mL 5.4466 mL 13.6166 mL
    10 mM 0.2723 mL 1.3617 mL 2.7233 mL 6.8083 mL
    15 mM 0.1816 mL 0.9078 mL 1.8155 mL 4.5389 mL
    20 mM 0.1362 mL 0.6808 mL 1.3617 mL 3.4041 mL
    25 mM 0.1089 mL 0.5447 mL 1.0893 mL 2.7233 mL
    30 mM 0.0908 mL 0.4539 mL 0.9078 mL 2.2694 mL
    40 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7021 mL
    50 mM 0.0545 mL 0.2723 mL 0.5447 mL 1.3617 mL
    60 mM 0.0454 mL 0.2269 mL 0.4539 mL 1.1347 mL
    80 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8510 mL
    100 mM 0.0272 mL 0.1362 mL 0.2723 mL 0.6808 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    TCS PIM-1 1
    目录号:
    HY-18086
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