1. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Metabolic Enzyme/Protease
  2. JAK Phosphodiesterase (PDE)
  3. TyK2-IN-2

TyK2-IN-2 (Compoud 18) 是一种有效的选择性 TYK2 抑制剂,对 TYK2 JH2IL-23IFNαIC50 值分别为 7 nM,0.1 μM 和 0.05 μM。TyK2-IN-2 还抑制磷酸二酯酶 4 (PDE4),其 IC50 为 62 nM。TyK2-IN-2 可用于炎症及自身免疫病的研究。

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TyK2-IN-2 Chemical Structure

TyK2-IN-2 Chemical Structure

CAS No. : 2098466-94-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2724
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1 mg ¥1330
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5 mg ¥3990
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10 mg ¥5800
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases[1].

IC50 & Target

Tyk2 JH2

7 nM (IC50)

PDE4

62 nM (IC50)

体外研究
(In Vitro)

A co-crystal structure of TyK2-IN-2 (Compoud 18) bound to the TYK2 JH2 is solved. First, limited room between C8 and the hinge is seen, consistent with the loss in affinity seen with groups larger than methylamino at this position. There are also hydrogen bonds revealed between the NH of the C8 methylamine and from N1 of the IZP core to the ‘hinge’ (Val690). Additional hydrogen bonds are observed from the oxygen of the C3 amide to Lys642 and to the hinge carbonyl of Glu688 through a bridging water molecule. The pocket proximal to the C3 amide of the TYK2 JH2 domain contains a combination of residues which are largely unique relative to the kinome such as a small residue (Ala671) under the “gatekeeper” (Thr687) and the replacement of the highly kinase-conserved DFG motif by DPG which alters the positioning of the conserved catalytic Lys642 and Asp759. The ability of the C3 amide to fit and bind to this pocket is believed to be a key source of kinome selectivity for TyK2-IN-2 (Compoud 18)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

310.35

Formula

C16H18N6O

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 25 mg/mL (80.55 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2222 mL 16.1108 mL 32.2217 mL
5 mM 0.6444 mL 3.2222 mL 6.4443 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.64%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2222 mL 16.1108 mL 32.2217 mL 80.5542 mL
5 mM 0.6444 mL 3.2222 mL 6.4443 mL 16.1108 mL
10 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0554 mL
15 mM 0.2148 mL 1.0741 mL 2.1481 mL 5.3703 mL
20 mM 0.1611 mL 0.8055 mL 1.6111 mL 4.0277 mL
25 mM 0.1289 mL 0.6444 mL 1.2889 mL 3.2222 mL
30 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6851 mL
40 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0139 mL
50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6111 mL
60 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
80 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0069 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TyK2-IN-2
目录号:
HY-101762
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