1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 15-PGDH

15-PGDH (15-羟基前列腺素脱氢酶)

15-Hydroxyprostaglandin dehydrogenase

15-PGDH (15-Hydroxyprostaglandin dehydrogenase) is a tumor suppressor in breast, colon, liver, lung, and pancreas since decreased expression of this enzyme is associated with increased tumorigenesis. 15-PGDH metabolizes intracellular PGE2 so that this ligand is unable to bind EP receptors, which results in suppression of PGE2 signaling.

The tumor suppressor 15-PGDH is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down-regulate 15-PGDH expression.

Inhibition of 15-PGDH, a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. 15-PGDH acts in vivo as a negative regulator of prostaglandin levels and activity, provides a candidate target.

15-PGDH 相关产品 (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16968
    SW033291 Inhibitor 99.74%
    SW033291 是一种有效且高亲和力的 15-PGDH 抑制剂,Ki 为 0.1 nM。SW033291 增加骨髓和其他组织中前列腺素 PGE2 的水平。SW033291 还可促进组织再生。
    SW033291
  • HY-151807
    15-PGDH-IN-1 Inhibitor 99.70%
    15-PGDH-IN-1 是一种有效的 15-PGDH 抑制剂,具有口服活性。15-PGDH-IN-1 对重组人 15-PGDH 具有抑制活性,IC50 值为 3 nM。15-PGDH-IN-1 可用于组织修复和再生的研究。
    15-PGDH-IN-1
  • HY-123548
    ML148 Inhibitor 99.89%
    ML148是一种有效的选择性 15-PGDH 抑制剂,其 IC50 值为 56 nM。 ML148 具有研究前列腺素信号通路的潜力。
    ML148
  • HY-124230
    15-PGDH-IN-3 Inhibitor
    15-PGDH-IN-3 (Compound 61) 是一种选择性的15-羟基前列腺素脱氢酶 (15-PGDH) 竞争性抑制剂。
    15-PGDH-IN-3
  • HY-116198
    15-PGDH-IN-2 Inhibitor
    15-PGDH-IN-2 ( Conpound 2) 是一种 15-PGDH 抑制剂 IC50 值为 0.274 nM。15-PGDH-IN-2 可以用于脱发,骨形成、胃溃疡愈合、皮肤伤口愈合的研究。
    15-PGDH-IN-2
  • HY-116096
    15-epi-PGE1 Inhibitor
    15-epi-PGE1 是 PGE1 的立体异构体,但生物活性较低。15-epi-PGE1 是人胎盘 15-羟基前列腺素脱氢酶 (15-PGDH) 的非竞争性抑制剂,IC50 为 170 μM。
    15-epi-PGE1