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ADCs Cytotoxin

A cytotoxin is any substance which has a toxic effect on cells. Some common examples of cytotoxins include chemical agents and certain snake venoms. Cytotoxins typically attack only a specific type of cell or organ, rather than an entire body. Cells that have been affected by a cytotoxin can perish in several different ways. One is necrosis. In this form of cell death, the cells lose integrity in their membrane wall and collapse. Another type of possible cell death is apoptosis. This type of death is pre-programmed into the cell itself before the cytotoxin arrives. It is typically a beneficial property, as seen when cells in the fingers and toes of developing human babies undergo apoptosis, leading to the separation of digits. Chemotherapy as a treatment of cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthy cells.

Antibody-drug conjugates cytotoxin (37)
产品名称 目录号 简述
10-Deacetyl-7-xylosyl paclitaxel HY-20584

10-Deacetyl-7-xylosyl paclitaxel是Paclitaxel的衍生物,相比Paclitaxel,具有更好的药学活性和水溶性。

alpha-Amanitin HY-19610

alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.

Ansamitocin P 3' HY-19839

Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin.

Ansamitocin P-3 HY-15739

Ansamitocin P-3是maytansine的类似物,对人实体瘤细胞系A-549和HT-29有较强的细胞毒性,可用于抗体偶联药物(ADC)。

Auristatin E HY-15582

Auristatin E是细胞毒性分子,微管蛋白修饰分子,强效抗肿瘤活性,MMAE的类似物以及在抗体药物偶连体开发中作为毒素分子。

Auristatin F HY-15583

Auristatin F是细胞毒性分子,微管蛋白修饰分子,强效抗肿瘤活性,MMAF的类似物以及在抗体药物偶连体开发中作为毒素分子。

Calicheamicin HY-19609

Calicheamicin is a potent DNA-binding cytotoxic antibiotic.

Campathecin HY-16560

Camptothecin (CPT)是拓扑异构酶I(topo I)抑制剂,对MDA-MB-231细胞的IC50和IC70分别为50 nM和0.225 _mu_M。

D8-MMAD HY-15581S

D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent.

D8-MMAE HY-15162A

D8-MMAE(D8-Monomethyl auristatin E; D8-Vedotin)是MMAE的氘代形式。

D8-MMAF HY-15579S

D8-MMAF is a deuterated form of MMAF, which is a microtubule disrupting agent.

Daun02 HY-13061

Daun02是daunorubicin b-galactoside原药。

Daunorubicin HY-13062A

Daunorubicin(RP13057)能抑制DNA和RNA合成,对DNA合成的Ki为0.02 μM。

Daunorubicin Hydrochloride HY-13062

Daunorubicin Hydrochloride (盐酸柔红霉素) 能抑制DNA和RNA合成,对DNA合成的Ki为0.02 _mu_M。

Dolastatin 10 HY-15580

Dolastatin 10(DLS 10;NSC 376128)是来自于海洋动物的抗有丝分裂多肽,能较强地抑制微管组装。Dolastatin及其类似物可用作抗体偶联药物(ADC)中的细胞毒性物。

DOXO-EMCH HY-16261A

INNO-206是doxorubicin的白蛋白结合原药,在酸性条件下可从白蛋白释放。

Doxorubicin HY-15142A

Doxorubicin(Adriamycin)为抗生素,能抑制DNA拓扑异构酶II,诱导DNA损伤和凋亡。

Doxorubicin hydrochloride HY-15142

Doxorubicin hydrochloride (多柔比星; Adriamycin) 为抗生素,能抑制DNA拓扑异构酶II,诱导DNA损伤和凋亡。

INNO-206 HY-16261

INNO-206 (Aldoxorubicin)是蒽环类抗生素doxorubicin (DOXO-EMCH)的原药,具有抗肿瘤活性。

Maytansinol HY-19474

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.

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