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ADCs Linker

Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody, a linker and a biological active cytotoxic. ADCs linkers are based on chemical motifs including disulfides, hydrazones or peptides (cleavable), or thioethers (noncleavable) and control the distribution and delivery of the cytotoxic agent to the target cell. Cleavable and noncleavable types of linkers have been proven to be safe in preclinical and clinical trials. A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC.

Antibody-drug conjugates linker (7)
产品名称 目录号 简述
(Ac)Phe-Lys(Alloc)-PABC-PNP HY-20560

(Ac)Phe-Lys(Alloc)-PABC-PNP是抗体偶联药物(ADC)的常用连接桥。

6-Maleimidohexanoic acid N-hydroxysuccinimide ester HY-78961

6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS)是抗体偶联药物(ADC)中常用保护基团。

6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- HY-21210

6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an useful linker for antibody-drug-conjugations (ADCs), extracted from [Bioorg Chem.

Fmoc-Val-Cit-PAB HY-19318

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

Fmoc-Val-Cit-PAB-PNP HY-41189

Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).

Mc-Val-Cit-PABC-PNP HY-20336

Mc-Val-Cit-PABC-PNP是可用组织蛋白酶切割的ADC多肽连接桥。 FDA批准的药物brentuximab vedotin采用了该接头。

Val-cit-PAB-OH HY-12362

Val-cit-PAB-OH is a peptide prodrug linker.

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