1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor 相关产品 (195):

Cat. No. Product Name Effect Purity
  • HY-B0468
    Isoprenaline hydrochloride Agonist >99.0%
    Isoprenaline hydrochloride 是一种非选择性的β肾上腺素受体 (beta-adrenergic receptor) 激动剂,用于治疗心跳过缓和心肌梗塞。
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist 99.75%
    Norepinephrine bitartrate monohydrate 是一种 β1- 选择性的肾上腺素能受体激动剂,EC50 为 5.37 μM。
  • HY-B0573
    Propranolol hydrochloride Antagonist 99.92%
    Propranolol hydrochloride是一种非选择性β-肾上腺素能受体(βAR)拮抗剂, IC50 值为12 nM。
  • HY-13951
    ICI 118,551 hydrochloride Antagonist 98.50%
    ICI 118,551 hydrochloride 是一种高度选择性的 β2 adrenergic receptor 拮抗剂,能够作用于β2,β1 和 β3 受体,Ki 值分别为 0.7,49.5 和 611 nM。
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist 98.10%
    (R)-(-)-Phenylephrine hydrochloride 是选择性的α1-肾上腺素受体激动剂,主要用作减充血剂。
  • HY-B0447B
    L-Epinephrine Agonist >99.0%
    L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergicβ-adrenergic受体激动剂。
  • HY-12987
    Pimozide Antagonist 98.01%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor 也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-103207
    Amibegron hydrochloride Agonist >99.0%
    Amibegron hydrochloride 是一种选择性的 β3-adrenoceptor 激动剂,对大鼠结肠 β-adrenoceptorEC50 值为 3.5 nM;Amibegron hydrochloride 具有抗焦虑和抗抑郁的活性。
  • HY-N0127
    Yohimbine Hydrochloride Antagonist 99.85%
    Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
  • HY-14773
    Mirabegron Agonist 99.08%
    Mirabegron 是一种选择性的肾上腺素受体 (β3-adrenoceptor) 激动剂,EC50 为 22.4 nM。
  • HY-B0362A
    Phentolamine mesylate Antagonist 99.83%
    Phentolamine甲磺酸是非选择性α-肾上腺素受体拮抗剂。
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor 98.39%
    Ivabradine hydrochloride 是一个新颖的 If 抑制剂,IC50值为 2.9 μM,用于降低心率。
  • HY-B0193A
    Prazosin hydrochloride Antagonist 99.73%
    Prazosin盐酸盐是α肾上腺素阻断剂,可作用于高血压、焦虑和恐慌症等。
  • HY-B0976A
    Fenoterol hydrobromide Agonist 99.71%
    Fenoterol溴酸盐是一个β 2肾上腺素能激动剂, 用于打通呼吸道到肺部, 被归类为交感神经β2激动剂和哮喘药物。
  • HY-B0437
    Sotalol hydrochloride Antagonist 99.77%
    Sotalol盐酸盐是肾上腺素受体拮抗剂,可作用于威胁生命的心律失常。
  • HY-14300A
    Vilanterol trifenatate Agonist 99.02%
    Vilanterol trifenatate 是一种长效的 β2-肾上腺素受体2-AR) 激动剂。作用于β2-AR,β1-AR 和 β3-AR,pEC50 分别为 10.37±0.05,6.98±0.03 和 7.36±0.03。
  • HY-17453
    Salmeterol xinafoate Agonist
    Salmeterol xinafoate 是长效 β2 肾上腺素能受体 (β2AR) 激动剂,对WT β2AR的Ki值为 1.5 nM。
  • HY-A0008
    B-HT 920 Agonist 99.99%
    B-HT 920(Talipexole 2Hcl)是多巴胺D2受体和α2-肾上腺素受体激动剂,5-HT3受体拮抗剂,有抗帕金森病活性。
  • HY-14299A
    Indacaterol maleate Agonist 99.92%
    Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。
  • HY-B0006
    Carvedilol Inhibitor 99.93%
    Carvedilol(BM14190)是非选择性β和α1阻断剂,能抑制LDL的氧化,IC50为3.8 μM。
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