1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor 相关产品 (155):

Cat. No. Product Name Effect Purity
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist 99.75%
    Norepinephrine bitartrate monohydrate 是一种 β1- 选择性的肾上腺素能受体激动剂,EC50 为 5.37 μM。
  • HY-B0468
    Isoprenaline hydrochloride Agonist 99.97%
    Isoprenaline hydrochloride 是一种非选择性的β肾上腺素受体 (beta-adrenergic receptor) 激动剂,用于治疗心跳过缓和心肌梗塞。
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist 99.40%
    (R)-(-)-Phenylephrine 盐酸盐是α1-肾上腺受体激动剂。
  • HY-B0573
    Propranolol hydrochloride Antagonist 99.57%
    Propranolol hydrochloride是一种非选择性β-肾上腺素能受体(βAR)拮抗剂, IC50 值为12 nM。
  • HY-13951
    ICI 118,551 hydrochloride Antagonist 99.00%
    ICI 118,551 hydrochloride 是一种高度选择性的 β2 adrenergic receptor 拮抗剂,能够作用于β2,β1 和 β3 受体,Ki 值分别为 0.7,49.5 和 611 nM。
  • HY-17380
    (S)-Timolol Maleate Antagonist 98.89%
    (S)-Timolol马来酸盐是非选择性β-肾上腺素受体拮抗剂,对β1和β2受体亚型的Ki分别为1.97和2.0 nM。
  • HY-B1614
    Clenbuterol hydrochloride Agonist 99.23%
    Clenbuterol hydrochloride是β2 adrenergic受体激动剂。它是一种强效的支气管扩张剂,具有脂肪燃烧性能。
  • HY-102032A
    (RS)-Butyryltimolol
    (RS)-Butyryltimolol 是 Butyryltimolol 的外消旋体。Butyryltimolol 是 Timolol 的丁酸酯。Timolol 是非选择性 β 受体阻滞剂。
  • HY-B0447B
    L-Epinephrine Agonist 99.87%
    L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergicβ-adrenergic受体激动剂。
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor 98.39%
    Ivabradine hydrochloride 是一个新颖的 If 抑制剂,IC50值为 2.9 μM,用于降低心率。
  • HY-17453
    Salmeterol xinafoate Agonist
    Salmeterol xinafoate 是长效 β2 肾上腺素能受体 (β2AR) 激动剂,对WT β2AR的Ki值为 1.5 nM。
  • HY-B0409A
    Clonidine hydrochloride Agonist 99.95%
    Clonidine hydrochloride 是 α2-adrenoceptor 激动剂,为一种有效的抗高血压药。
  • HY-N0127
    Yohimbine Hydrochloride Antagonist 99.79%
    Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
  • HY-B0362A
    Phentolamine mesylate Antagonist 99.42%
    Phentolamine甲磺酸是非选择性α-肾上腺素受体拮抗剂。
  • HY-A0077
    Perphenazine Inhibitor 99.93%
    Perphenazine 是一种典型的抗精神病药物, 抑制5-HT2A 受体(5-HT2A), Alpha-1A肾上腺素受体(α1A), 多巴胺受体D2/D3, D2L, 和组胺 H1 受体 (H1), Ki值分别为5.6, 10, 0.765/0.13, 3.4, 和 8 nM.
  • HY-14300A
    Vilanterol trifenatate Agonist
    Vilanterol trifenatate 是一种长效的 β2-肾上腺素受体2-AR) 激动剂。作用于β2-AR,β1-AR 和 β3-AR,pEC50 分别为 10.37±0.05,6.98±0.03 和 7.36±0.03。
  • HY-10122
    Silodosin Antagonist 99.29%
    Silodosin (Rapaflo; KMD-3213)是α1-肾上腺素受体拮抗剂。
  • HY-B0431A
    Phenoxybenzamine hydrochloride Antagonist >98.0%
    Phenoxybenzamine hydrochloride 是具有选择行的 α-adrenoceptorcalmodulin 的抑制剂,是一种常用的抗高血压药。
  • HY-12380
    Atipamezole hydrochloride Antagonist
    Atipamezole hydrochloride是合成的α2-肾上腺素受体拮抗剂, Ki值为1.6 nM。
  • HY-14773
    Mirabegron Agonist 99.86%
    Mirabegron 是一种选择性的肾上腺素受体 (β3-adrenoceptor) 激动剂,EC50 为 22.4 nM。