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Antibody-drug Conjugates

  Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody linked, via a stable, chemical, linker with labile bonds, to a biological active cytotoxic (anticancer) payload or drug. By combining the unique targeting capabilities of monoclonal antibodies with the cancer-killing ability of cytotoxic drugs, antibody-drug conjugates allow sensitive discrimination between healthy and diseased tissue. This means that, in contrast to traditional chemotherapeutic agents, antibody-drug conjugates target and attack the cancer cell so that healthy cells are less severely affected.  

Antibody-drug conjugates (14)
产品名称 目录号 简述
Acetylene-linker-Val-Cit-PABC-MMAE HY-19812

Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE),  Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.

Cys-mcMMAD HY-15750

Monomethyl auristatin D (MMAD)是微管蛋白抑制剂,是抗体偶联药物(ADC)中的毒素载荷。

Fmoc-Val-Cit-PAB-MMAE HY-19811

Fmoc-Val-Cit-PAB-MMAE consists the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), Fmoc-Val-Cit-PAB-MMAE is an antibody drug conjugate.

MAL-di-EG-Val-Cit-PAB-MMAE HY-100567

MAL-di-EG-Val-Cit-PAB-MMAE consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), MAL-di-EG-Val-Cit-PAB-MMAE is an antibody drug conjugate.

Mc-MMAD HY-15740

Mc-MMAE由高效微管抑制剂Monomethyl auristatin D(MMAD)与保护基团maleimidocaproyl偶联而成。

Mc-MMAE HY-15741

Mc-MMAE由高效微管抑制剂Monomethyl auristatin E(MMAE)与保护基团maleimidocaproyl偶联而成。

McMMAF HY-15578

Mc-MMAF is a protective group-conjugated MMAF.

mDPR-Val-Cit-PAB-MMAE HY-19813

mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate.

N3-PEG3-vc-PAB-MMAE HY-100874

N3-PEG3-vc-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the peptide N3-PEG3-vc-PAB.

SMCC-DM1 HY-101070

SMCC-DM1 is DM1 with a reactive linker SMCC to make antibody drug conjugate.

SuO-Val-Cit-PAB-MMAE HY-100566

SuO-Val-Cit-PAB-MMAE consists of the ADCs linker (SuO-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), SuO-Val-Cit-PAB-MMAE is an antibody-drug conjugate.

Val-Cit-PAB-MMAE HY-100374

Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate.

Vc-MMAD HY-15742

Vc-MMAD为抗体偶联药物(ADC),由Val-Cit作为linker,连接微管抑制剂MMAD。

VcMMAE HY-15575

VcMMAE是抗体偶联药物(ADC)中的抗有丝分裂剂,由一甲基阿里他汀E(MMAE)与二肽缬氨酸-瓜氨酸(Vc)交联而成。

Tags: Antibody-drug conjugates 抑制 | Antibody-drug conjugates 蛋白 | Antibody-drug conjugates 抑制剂 | Antibody-drug conjugates FDA上市药物 | Antibody-drug conjugates 和癌症 | Antibody-drug conjugates 活性 | Antibody-drug conjugates 激活 | Antibody-drug conjugates 信号通路 | Antibody-drug conjugates 抑制剂筛选 | Antibody-drug conjugates 高通量筛选 | Antibody-drug conjugates 抑制剂临床 | Antibody-drug conjugates 抑制剂药物 | Antibody-drug conjugates 抑制剂综述 | Antibody-drug conjugates 抑制剂研发 | Antibody-drug conjugates 抑制剂供应商 | Antibody-drug conjugates 抑制剂分销商

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