首页 产品 化合物库 服务 Kit 关于我们 联系我们

信号通路

在线客服 在线询单 如何订购 促销产品 销售网络 定制服务

在线询价

温馨提示:客服在线时为9:00-18:00,
其他时间可发邮件至sales@medchemexpress.cn,我们会尽快回复您。

Antifungal

 

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

 

Antifungal (68)
产品名称 目录号 简述
(+)-Ketoconazole HY-B0105A

(+)-Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 inhibitor.

10-Undecenoic acid zinc salt HY-B0914A

10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

3-(Methylthio)propionic acid HY-101401

3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.

4',7-Dimethoxyisoflavone HY-N2145

4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity.

Amorolfine hydrochloride HY-B0238

Amorolfine hydrochloride (盐酸阿莫罗芬) 是抗真菌剂。

Amphotericin B HY-B0221

Amphotericin B (两性霉素B) 是抗真菌类抗生素,由结节链霉菌中的一种菌株产生,IC50为0.028到0.290 μg/ml。

AN-2690 HY-10980

AN-2690(Tavaborole)是抗真菌剂,对发癣菌属有抑制性,对甲癣有潜在应用可能。

Anidulafungin HY-13553

Anidulafungin (阿尼芬净; LY303366) 是半合成的echinocandin,可通过抑制真菌细胞壁中的(1,3)-beta-D-glucan的合成起到抗真菌的作用。

Ascomycin HY-13557

Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物,具有很强的免疫抑制剂。

Bifonazole HY-B0301

Bifonazole (联苯苄唑) 是咪唑类抗真菌剂。

Butenafine Hydrochloride HY-17396

Butenafine Hydrochloride (盐酸布替萘芬) 具有抗真菌活性,能通过抑制鲨烯环氧酶阻断甾醇的合成。

Butoconazole nitrate HY-B0293

Butoconazole nitrate (硝酸布康唑) 是抗真菌剂。

Caspofungin Acetate HY-17006

Caspofungin Acetate (醋酸卡泊芬净; Cancidas; L 743872; L 743873; MK 0991) 是抗真菌剂。

Cercosporamide HY-16982

Cercosporamide is a potent and selective Mnk inhibitor, and a orally bioavailable antifungal agent, suppresses phosphorylation of eIF4E and exhibits antileukemic effects.

Chlorquinaldol HY-B1360

Chlorquinaldol  is a mono-hydroxyquinoline, is an antifungal and antibacterial, used for topical treatment of skin conditions and vaginal infections.

Ciclopirox HY-B0450

Ciclopirox (环吡酮; Penlac)是合成的抗真菌化合物。

Ciclopirox olamine HY-B0450A

Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.

Climbazole HY-B1151

Climbazole is a topical antifungal agent, commonly used in the treatment of human fungal skin infections, such as dandruff and eczema.

Clioquinol HY-14603

Clioquinol (氯碘羟喹; Iodochlorhydroxyquin) 是一抗真菌化合物,近来被研究发现有抗AD和抗肿瘤活性。

Clotrimazole HY-10882

Clotrimazole (克霉唑) 是咪唑衍生物,有抗真菌活性,是P450抑制剂。

Tags: Antifungal 抑制 | Antifungal 蛋白 | Antifungal 抑制剂 | Antifungal FDA上市药物 | Antifungal 和癌症 | Antifungal 活性 | Antifungal 激活 | Antifungal 信号通路 | Antifungal 抑制剂筛选 | Antifungal 高通量筛选 | Antifungal 抑制剂临床 | Antifungal 抑制剂药物 | Antifungal 抑制剂综述 | Antifungal 抑制剂研发 | Antifungal 抑制剂供应商 | Antifungal 抑制剂分销商

SiteMap

MCE所有的产品和服务只应用于科学研究,我们不提供产品和服务给任何个人。

Copyright © 2013-2014 MedChemexpress All Rights Reserved 沪ICP备15051369号-1