1. Cytoskeleton
  2. Arp2/3 Complex

Arp2/3 Complex

The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.

The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.

Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.

Arp2/3 Complex 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-15892
    CK-636 Inhibitor 98.10%
    CK-636(CK-0944636)是Arp2/3复合物抑制剂,能抑制肌动蛋白的聚合,可渗透入细胞,对人,裂殖酵母和牛的Arp2/3复合物的IC50分别为4μM,24μM和32μM。