1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Aryl Hydrocarbon Receptor 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-15484
    Pifithrin-α hydrobromide Agonist 98.28%
    Pifithrin-α hydrobromide是 p53 抑制剂,可阻断其转录活性并阻止细胞凋亡。
  • HY-15001
    StemRegenin 1 Antagonist 99.50%
    StemRegenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.
  • HY-12451
    FICZ Agonist 98.19%
    FICZ是有效的芳烃受体 (AhR) 激动剂,Kd值为70 pM。
  • HY-19317
    ITE Agonist >98.0%
    ITE 是一种有效的内源性芳香烃受体 (AhR) 激动剂,能够直接与 AHR 结合,Ki 值为 3 nM。ITE 具有免疫抑制作用。
  • HY-104026
    L-Kynurenine Agonist 99.40%
    L-Kynurenine是L-色氨酸的代谢物。它是一种芳香烃受体 (aryl hydrocarbon receptor) 激动剂。
  • HY-112627
    CAY 10465 Agonist 98.48%
    CAY 10465 是一种选择性的,高亲和性的芳香烃受体 (AhR) 激动剂,Ki 值为 0.2 nM,对雌激素受体 (estrogen receptor) 无作用 (Ki >100000 nM)。
  • HY-112629
    PDM2 Antagonist 98.88%
    PDM2 是一种选择性的高亲和力芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。
  • HY-109044
    Tapinarof Agonist 99.74%
    Tapinarof 是一种天然的芳烃受体 (AhR) 激动剂,EC50 为 13 nM。
  • HY-N0178
    Diosmin Agonist >98.0%
    Diosmin 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体 (AhR) 的激动剂。
  • HY-N0170
    Indole-3-carbinol Agonist >98.0%
    Indole-3-carbinol 是芳烃受体 (AhR) 的激动剂。
  • HY-100242
    Mivotilate Activator >98.0%
    Mivotilate 是一种非毒性的,有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂,具有护肝作用。
  • HY-111441
    1,4-Chrysenequinone Activator
    1,4-Chrysenequinone 是一种多环芳香烃类,可以作为芳香烃受体 (AhR) 的激活剂起作用。
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