1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR

CXCR

CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span thecell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7. CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCR3 is expressed predominantly on T lymphocytes. CXCR4 is the receptor for a chemokine known as CXCL12 (or SDF-1) and, as with CCR5, is utilized by HIV-1 to gain entry into target cells. The chemokine receptor CXCR5 is selectively expressed on B cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. CXCR6 was formerly called three different names (STRL33, BONZO, and TYMSTR) before being assigned CXCR6 based on its chromosomal location and its similarity to other chemokine receptors in its gene sequence. CXCR7 was originally called RDC-1 (an orphan receptor) but has since been shown to cause chemotaxis in T lymphocytes in response to CXCL12 (the ligand for CXCR4) prompting the renaming of this molecule as CXCR7.

CXCR 相关产品 (30):

Cat. No. Product Name Effect Purity
  • HY-50912
    Plerixafor octahydrochloride Antagonist 98.90%
    Plerixafor octahydrochloride 是一种选择性的 CXCR4 拮抗剂,IC50 为 44 nM。
  • HY-15251
    Reparixin Inhibitor 99.88%
    Reparixin 是一种有效的 CXCL8 受体 CXCR1/2 变构抑制剂,微弱抑制 CXCR2- 调节的细胞迁移 (IC50=100 nM),但强抑制 CXCR1- 调节的细胞趋化 (IC50=1 nM)。
  • HY-10046
    Plerixafor Antagonist
    Plerixafor 是一种选择性的 CXCR4 拮抗剂,IC50 为 44 nM。
  • HY-10198
    SCH 527123 Antagonist 99.06%
    SCH 527123 是一种有效的 CXCR1CXCR2 的别构拮抗剂,IC50 分别为 1000 nM 和 3-6 nM。
  • HY-15252
    Reparixin L-lysine salt Inhibitor 98.87%
    Reparixin L-lysine salt 是一种有效的 CXCL8 受体 CXCR1/2 变构抑制剂,微弱抑制 CXCR2- 调节的细胞迁移 (IC50=100 nM),但强抑制 CXCR1- 调节的细胞趋化 (IC50=1 nM)。
  • HY-12488
    LY2510924 Inhibitor >98.0%
    LY2510924是有效,选择性的CXCR4拮抗剂;阻止SDF-1结合CXCR4的IC50值为0.079 nM。
  • HY-101458A
    IT1t dihydrochloride Antagonist 98.09%
    IT1t dihydrochloride是高效的CXCR4拮抗剂;抑制CXCL12/CXCR4相互作用的IC50值为2.1 nM。
  • HY-101022
    CXCR2-IN-1 Inhibitor 98.81%
    CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂,pIC50值为9.3。
  • HY-19768
    Danirixin Antagonist 98.23%
    Danirixin 是一种选择性的,可逆的 CXCR2 拮抗剂,也可抑制 CXCL8,其 IC50 值为 12.5 nM。
  • HY-10017
    SCH 546738 Antagonist 99.20%
    SCH 546738 是一种有效的非竞争性CXCR3 拮抗剂,结合到人CXCR3 受体的亲和常数 (Ki) 为 0.4 nM。
  • HY-16711
    SB225002 Antagonist 99.58%
    SB225002 是一种有效的选择性 CXCR2 拮抗剂,IC50 为 22 nM。
  • HY-15319
    AMG 487 Inhibitor 99.65%
    AMG 487 是一种有效的趋化因子受体 CXCR3 拮抗剂,能够抑制 125I-IP-10 和 125I-ITAC 与 CXCR3 结合,IC50 值分别为 8.0 和 8.2 nM。
  • HY-15971
    AMD 3465 hexahydrobromide Antagonist 98.79%
    AMD 3465 hexahydrobromide 是一种有效的,选择性的 CXCR4 拮抗剂,抑制 SDF-1α-配基结合,Ki 值为 41.7 nM。
  • HY-50101A
    AMD-070 hydrochloride Antagonist 99.56%
    AMD-070 hydrochloride 是一种有效的,具有选择性的 CXCR4 拮抗剂,在 CXCR4 125I-SDF 抑制结合试验中,IC50 值为 13 nM。
  • HY-10011
    SCH 563705 Antagonist
    SCH 563705是CXCR2和CXCR1拮抗剂,IC50分别为1.3 nM和7.3 nM。
  • HY-15320
    NBI-74330 Antagonist >98.0%
    NBI-74330 是一种有效的 CXCR3 拮抗剂,能够抑制 (125I)CXCL10 和 (125I)CXCL11 的特异性结合,Ki 值分别为 1.5 和 3.2 nM。
  • HY-13696
    MSX-122 Antagonist 99.74%
    MSX-122是一种新型小分子CXCR4 拮抗剂, 有效抑制 CXCR4/CXCL12 (IC50值为10 nM)。
  • HY-15478
    WZ811 Antagonist 99.74%
    WZ811是高效CXCR4拮抗剂,EC50为0.3 nM。
  • HY-15462
    SRT3109 Antagonist
    SRT3109是CXCR2拮抗剂,可作用于趋化因子介导的各种疾病。
  • HY-101458
    IT1t Antagonist
    IT1t是高效的CXCR4拮抗剂;抑制CXCL12/CXCR4相互作用的IC50值为2.1 nM。