1. GPCR/G Protein
  2. CXCR


CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span thecell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7. CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCR3 is expressed predominantly on T lymphocytes. CXCR4 is the receptor for a chemokine known as CXCL12 (or SDF-1) and, as with CCR5, is utilized by HIV-1 to gain entry into target cells. The chemokine receptor CXCR5 is selectively expressed on B cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. CXCR6 was formerly called three different names (STRL33, BONZO, and TYMSTR) before being assigned CXCR6 based on its chromosomal location and its similarity to other chemokine receptors in its gene sequence. CXCR7 was originally called RDC-1 (an orphan receptor) but has since been shown to cause chemotaxis in T lymphocytes in response to CXCL12 (the ligand for CXCR4) prompting the renaming of this molecule as CXCR7.

CXCR 相关产品 (30):

Cat. No. Product Name Effect Purity
  • HY-50912
    Plerixafor octahydrochloride Antagonist 98.90%
    Plerixafor octahydrochloride 是一种选择性的 CXCR4 拮抗剂,IC50 为 44 nM。
  • HY-10046
    Plerixafor Antagonist >98.0%
    Plerixafor 是一种选择性的 CXCR4 拮抗剂,IC50 为 44 nM。
  • HY-15251
    Reparixin Inhibitor 99.88%
    Reparixin 是一种有效的 CXCL8 受体 CXCR1/2 变构抑制剂,微弱抑制 CXCR2- 调节的细胞迁移 (IC50=100 nM),但强抑制 CXCR1- 调节的细胞趋化 (IC50=1 nM)。
  • HY-15252
    Reparixin L-lysine salt Inhibitor 98.38%
    Reparixin L-lysine salt 是一种有效的 CXCL8 受体 CXCR1/2 变构抑制剂,微弱抑制 CXCR2- 调节的细胞迁移 (IC50=100 nM),但强抑制 CXCR1- 调节的细胞趋化 (IC50=1 nM)。
  • HY-10198
    SCH 527123 Antagonist 99.06%
    SCH 527123 是一种有效的 CXCR1CXCR2 的别构拮抗剂,IC50 分别为 1000 nM 和 3-6 nM。
  • HY-15319
    AMG 487 Inhibitor 99.65%
    AMG 487 是一种有效的趋化因子受体 CXCR3 拮抗剂,能够抑制 125I-IP-10 和 125I-ITAC 与 CXCR3 结合,IC50 值分别为 8.0 和 8.2 nM。
  • HY-19768
    Danirixin Antagonist 98.23%
    Danirixin 是一种选择性的,可逆的 CXCR2 拮抗剂,也可抑制 CXCL8,其 IC50 值为 12.5 nM。
  • HY-16711
    SB225002 Antagonist 99.58%
    SB225002 是一种有效的选择性 CXCR2 拮抗剂,IC50 为 22 nM。
  • HY-10017
    SCH 546738 Antagonist 99.20%
    SCH 546738 是一种有效的非竞争性CXCR3 拮抗剂,结合到人CXCR3 受体的亲和常数 (Ki) 为 0.4 nM。
  • HY-15971
    AMD 3465 hexahydrobromide Antagonist 98.79%
    AMD 3465 hexahydrobromide 是一种有效的,选择性的 CXCR4 拮抗剂,抑制 SDF-1α-配基结合,Ki 值为 41.7 nM。
  • HY-12488
    LY2510924 Inhibitor >98.0%
    LY2510924是有效,选择性的CXCR4拮抗剂;阻止SDF-1结合CXCR4的IC50值为0.079 nM。
  • HY-50101A
    AMD-070 hydrochloride Antagonist 99.56%
    AMD-070 hydrochloride 是一种有效的,具有选择性的 CXCR4 拮抗剂,在 CXCR4 125I-SDF 抑制结合试验中,IC50 值为 13 nM。
  • HY-10011
    SCH 563705 Antagonist
    SCH 563705是CXCR2和CXCR1拮抗剂,IC50分别为1.3 nM和7.3 nM。
  • HY-13696
    MSX-122 Antagonist 99.74%
    MSX-122是一种新型小分子CXCR4 拮抗剂, 有效抑制 CXCR4/CXCL12 (IC50值为10 nM)。
  • HY-P0171
    BKT140 Antagonist 99.19%
    BKT140是一种新型的CXCR4拮抗剂, IC50约为1 nM.
  • HY-19855
    AZD-5069 Antagonist 98.97%
    AZD-5069 是有效的 CXCR2 chemokine 受体拮抗剂,用于癌症治疗。
  • HY-15320
    NBI-74330 Antagonist >98.0%
    NBI-74330 是一种有效的 CXCR3 拮抗剂,能够抑制 (125I)CXCL10 和 (125I)CXCL11 的特异性结合,Ki 值分别为 1.5 和 3.2 nM。
  • HY-15478
    WZ811 Antagonist 99.74%
    WZ811是高效CXCR4拮抗剂,EC50为0.3 nM。
  • HY-N0011
    Baohuoside I Inhibitor 98.83%
    Baohuoside I (Icariside-II)是朝鲜淫羊藿提取物,被证明是CXCR4表达调节剂以及癌细胞凋亡诱导剂。
  • HY-101458A
    IT1t dihydrochloride Antagonist 98.09%
    IT1t dihydrochloride是高效的CXCR4拮抗剂;抑制CXCL12/CXCR4相互作用的IC50值为2.1 nM。