1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-13233A
    Talabostat mesylate Inhibitor >98.0%
    Talabostat mesylate 是高效,非选择性的,具有口服活性的二肽基肽酶 IV (DPP-IV) 抑制剂,Ki 值为 0.18 nM。
  • HY-13749
    Sitagliptin Inhibitor 99.72%
    Sitagliptin 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  • HY-10284
    Linagliptin Inhibitor 99.62%
    Linagliptin 是一种有效的,选择性的 DPP-4 抑制剂,IC50 值为 1 nM。
  • HY-13749B
    Sitagliptin phosphate monohydrate Inhibitor 99.78%
    Sitagliptin(MK 0431)是DPP4高效抑制剂,在Caco-2细胞中IC50值为19nM。
  • HY-14806
    Teneligliptin Inhibitor 99.82%
    Teneligliptin 是一种有效的 DPP-4 抑制剂,竞争性抑制人血浆,大鼠血浆和人重组DPP-4,IC50 约为 1 nM。
  • HY-14892
    Gemigliptin Inhibitor 98.31%
    Gemigliptin是高度选择性的二肽基肽酶4 (dipeptidyl peptidase 4 (DPP4)) 抑制剂。
  • HY-N6584
    Saikogenin A Inhibitor 98.31%
    Saikogenin A 可从中药柴胡中提取,是一种二肽基肽酶 IV (DPP-IV) 抑制剂。
  • HY-112668
    Retagliptin Phosphate Inhibitor 99.69%
    Retagliptin Phosphate 是 DPP-4 的抑制剂,可用于治疗 2 型糖尿病。
  • HY-14291
    Vildagliptin Inhibitor 98.03%
    Vildagliptin (LAF-237; NVP-LAF 237)能抑制DPP-4,IC50为2.3 nM。
  • HY-10285
    Saxagliptin Inhibitor 98.03%
    Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂,IC50和Ki分别为26 nM和1.3 nM。
  • HY-A0023
    Alogliptin Benzoate Inhibitor 99.93%
    Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。
  • HY-15981
    Omarigliptin Inhibitor 99.91%
    Omarigliptin(MK-3102)是DPP4高效选择性抑制剂,IC50值为1.6nM。
  • HY-101056
    AZD7986 Inhibitor 99.07%
    AZD7986 是一个二肽基肽酶 1 (DPP1) 抑制剂,在人,小鼠,大鼠,狗和兔中的 pIC50 值分别为 6.85, 7.6, 7.7, 7.8 和 7.8。
  • HY-14877
    Anagliptin Inhibitor
    Anagliptin 是一种高选择性的,有效的二肽酰肽酶 4 (DPP-4) 抑制剂,IC50 值为 3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50 值分别为 68 和 60 nM。
  • HY-15408
    Trelagliptin Inhibitor 99.89%
    Trelagliptin(SYR-472)是长效的DPP4抑制剂,可作用于2型糖尿病。
  • HY-14806A
    Teneligliptin hydrobromide Inhibitor 99.99%
    Teneligliptin是新型长效DPP-4高活性抑制剂,竞争性抑制人和大鼠血浆中DPP-4及人重组型DPP-4,IC50为1 nM。
  • HY-15408A
    Trelagliptin succinate Inhibitor 99.89%
    Trelagliptin(SYR-472)是长效的DPP-4抑制剂。
  • HY-13233
    Talabostat Inhibitor
    Talabostat (PT100, Val-boroPro) 是高效,非选择性,具有口服活性的二肽基肽酶IV (DPP-IV) 抑制剂,Ki 值为0.18 nM。
  • HY-108319
    DPP-IV-IN-2 Inhibitor >98.0%
    DPP-IV-IN-2 是二肽基肽酶 IV (DPIV) 和 DP8/9 的抑制剂, 其 IC50 值分别为 0.1 和 0.95 μM。
  • HY-101769
    UAMC00039 dihydrochloride Inhibitor 98.44%
    UAMC00039 dihydrochloride是高效,可逆,竞争性的dipeptidyl peptidase II抑制剂,IC50值为0.48 nM。
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