1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase 相关产品 (22):

Cat. No. Product Name Effect Purity
  • HY-13233A
    Talabostat mesylate Inhibitor
    Talabostat mesylate 是一种可口服的,特异性的 dipeptidyl peptidases 抑制剂,能够抑制DPP4的活性,IC50 值为 1 nM。
  • HY-13749
    Sitagliptin Inhibitor 99.95%
    Sitagliptin 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  • HY-10285
    Saxagliptin Inhibitor 98.03%
    Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂,IC50和Ki分别为26 nM和1.3 nM。
  • HY-10284
    Linagliptin Inhibitor 99.62%
    Linagliptin 是一种有效的,选择性的 DPP-4 抑制剂,IC50 值为 1 nM。
  • HY-14806
    Teneligliptin Inhibitor 99.82%
    Teneligliptin 是一种有效的 DPP-4 抑制剂,竞争性抑制人血浆,大鼠血浆和人重组DPP-4,IC50 约为 1 nM。
  • HY-101769
    UAMC00039 dihydrochloride Inhibitor 98.44%
    UAMC00039 dihydrochloride是高效,可逆,竞争性的dipeptidyl peptidase II抑制剂,IC50值为0.48 nM。
  • HY-13233
    Talabostat Inhibitor
    Talabostat (PT100, Val-boroPro) 是高效,非选择性,具有口服活性的二肽基肽酶IV (DPP-IV) 抑制剂,Ki 值为0.18 nM。
  • HY-13749B
    Sitagliptin phosphate monohydrate Inhibitor 99.72%
    Sitagliptin(MK 0431)是DPP4高效抑制剂,在Caco-2细胞中IC50值为19nM。
  • HY-15981
    Omarigliptin Inhibitor 99.91%
    Omarigliptin(MK-3102)是DPP4高效选择性抑制剂,IC50值为1.6nM。
  • HY-14877
    Anagliptin Inhibitor 98.05%
    Anagliptin是DPP-4高效选择性抑制剂,IC50值3.8nM,对DPP-8和DPP-9活性弱10倍以上。
  • HY-14291
    Vildagliptin Inhibitor
    Vildagliptin (LAF-237; NVP-LAF 237)能抑制DPP-4,IC50为2.3 nM。
  • HY-A0023
    Alogliptin Benzoate Inhibitor 99.93%
    Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。
  • HY-15408
    Trelagliptin Inhibitor 99.54%
    Trelagliptin(SYR-472)是长效的DPP4抑制剂,可作用于2型糖尿病。
  • HY-15408A
    Trelagliptin succinate Inhibitor 99.89%
    Trelagliptin(SYR-472)是长效的DPP-4抑制剂。
  • HY-14806A
    Teneligliptin hydrobromide Inhibitor 99.99%
    Teneligliptin是新型长效DPP-4高活性抑制剂,竞争性抑制人和大鼠血浆中DPP-4及人重组型DPP-4,IC50为1 nM。
  • HY-12528
    DBPR108 Inhibitor
    DBPR108是DPP4新型具口服活性选择性抑制剂,IC50值为15nM,对DPP8和DPP9基本无抑制。
  • HY-A0023A
    Alogliptin Inhibitor
    Alogliptin(SYR-322)是高活性DPP4选择性抑制剂,IC50<10 nM,比对DPP8和DPP9的抑制性高10000倍以上。
  • HY-101605
    Prodipine hydrochloride Inhibitor
    Prodipine 是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶 IV (DPP IV),IC50 分别为 4.5 μM 和 30 μM。
  • HY-10287
    Gosogliptin Inhibitor
    Gosogliptin 是一种有效的选择性二肽基肽酶IV (DPP-IV) 抑制剂。
  • HY-10286
    Dutogliptin Inhibitor
    Dutogliptin 是一种口服有效的选择性二肽基肽酶-4 (DPP4) 抑制剂。